ID   LCORL_CHICK             Reviewed;         600 AA.
AC   Q5ZJK5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Ligand-dependent nuclear receptor corepressor-like protein;
GN   Name=LCORL; ORFNames=RCJMB04_17h17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May act as transcription activator that binds DNA elements
CC       with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG32088.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAG32088.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ720429; CAG32088.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001026331.1; NM_001031160.1.
DR   RefSeq; XP_015141205.1; XM_015285719.1.
DR   AlphaFoldDB; Q5ZJK5; -.
DR   SMR; Q5ZJK5; -.
DR   STRING; 9031.ENSGALP00000028143; -.
DR   PaxDb; Q5ZJK5; -.
DR   Ensembl; ENSGALT00000028196; ENSGALP00000028143; ENSGALG00000014421.
DR   GeneID; 422820; -.
DR   KEGG; gga:422820; -.
DR   CTD; 254251; -.
DR   VEuPathDB; HostDB:geneid_422820; -.
DR   eggNOG; KOG4565; Eukaryota.
DR   GeneTree; ENSGT00940000162414; -.
DR   HOGENOM; CLU_040042_0_0_1; -.
DR   InParanoid; Q5ZJK5; -.
DR   OMA; CKNSKPV; -.
DR   OrthoDB; 47456at2759; -.
DR   PhylomeDB; Q5ZJK5; -.
DR   PRO; PR:Q5ZJK5; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000014421; Expressed in spermatid and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR007889; HTH_Psq.
DR   Pfam; PF05225; HTH_psq; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS50960; HTH_PSQ; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..600
FT                   /note="Ligand-dependent nuclear receptor corepressor-like
FT                   protein"
FT                   /id="PRO_0000310465"
FT   DOMAIN          514..566
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DNA_BIND        542..562
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          581..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  67186 MW;  9D933E9D35F823AB CRC64;
     MEKGTDRMAA AAPAPPAAAS QCRSPRCTAE RRGVRRELDS WRHRLMHCVG FESILEGLYG
     PRLRRDLSLF EDCEPEELTD WSMDEKCSFC NLHKETVSDR ASVIGSSQST PTEELSSQGQ
     SNTDKIECQA ENYLNALFRK KDLPQNCDPN IPLVAQELMK KMIRQFAIEY ISKSSKIQEN
     RNGSSFEPSL ICKSIQMNQT ENSLQEEQDS PLDLTVNRTQ EQNTQQGDGV LDLSTKKSAR
     LEEPKYDPLC SENSVSGRLH RHREDYVERS AEFADGLLSK ALKDIQSGAL DINKAGILYG
     IPQKTLLLHL EALPAGKPAP FKNKTRDFND SYSFKDSKET CAVLQKVALW ARAQAERTEK
     SKLSLLETSE LKFPTASSYL HQLTLQRMVT QFKEKSENLQ YETTNPTVQL KIPQLRISSV
     SKPQSDTAGL LDVMYHVSKT SSVLEGSALQ KLKNILPKQN KIECSGPVTH SSVDSYFLHG
     DLSPLCLNAK NGTVDGTSEN TEDSLDRKDN KQPRKKRGRY RQYDHEIMEE AIAMVMSGKM
     SVSKAQGIYG VPHSTLEYKV KERSGTLKTP PKKKLRLPDT GLFNMTDSGT GSCKTSSKPV