LCORL_HUMAN
ID LCORL_HUMAN Reviewed; 602 AA.
AC Q8N3X6; Q96NK1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 4.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Ligand-dependent nuclear receptor corepressor-like protein;
DE Short=LCoR-like protein;
GN Name=LCORL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-242; LYS-319; LYS-340 AND
RP LYS-397, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May act as transcription activator that binds DNA elements
CC with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in
CC spermatogenesis (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N3X6; Q13363: CTBP1; NbExp=6; IntAct=EBI-7138654, EBI-908846;
CC Q8N3X6; P43360: MAGEA6; NbExp=3; IntAct=EBI-7138654, EBI-1045155;
CC Q8N3X6-3; P56545-3: CTBP2; NbExp=3; IntAct=EBI-12111580, EBI-10171902;
CC Q8N3X6-3; P43360: MAGEA6; NbExp=3; IntAct=EBI-12111580, EBI-1045155;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N3X6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N3X6-2; Sequence=VSP_029287;
CC Name=3;
CC IsoId=Q8N3X6-3; Sequence=VSP_029288, VSP_029289;
CC -!- CAUTION: A report observed N-glycosylation at Asn-493
CC (PubMed:19139490). However, as the protein is predicted to act as a
CC DNA-binding transcription activator, additional evidence is required to
CC confirm this result. {ECO:0000305|PubMed:19139490}.
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DR EMBL; AK055258; BAB70892.1; -; mRNA.
DR EMBL; AC005768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC079399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471069; EAW92786.1; -; Genomic_DNA.
DR EMBL; BC037322; AAH37322.3; -; mRNA.
DR CCDS; CCDS3425.1; -. [Q8N3X6-3]
DR CCDS; CCDS54749.1; -. [Q8N3X6-1]
DR RefSeq; NP_001159611.1; NM_001166139.2. [Q8N3X6-1]
DR RefSeq; NP_710153.2; NM_153686.8. [Q8N3X6-3]
DR AlphaFoldDB; Q8N3X6; -.
DR SMR; Q8N3X6; -.
DR BioGRID; 129025; 10.
DR IntAct; Q8N3X6; 5.
DR MINT; Q8N3X6; -.
DR STRING; 9606.ENSP00000371661; -.
DR GlyConnect; 2054; 1 N-Linked glycan (1 site).
DR GlyGen; Q8N3X6; 1 site, 2 N-linked glycans (1 site).
DR iPTMnet; Q8N3X6; -.
DR PhosphoSitePlus; Q8N3X6; -.
DR BioMuta; LCORL; -.
DR DMDM; 160395582; -.
DR EPD; Q8N3X6; -.
DR jPOST; Q8N3X6; -.
DR MassIVE; Q8N3X6; -.
DR MaxQB; Q8N3X6; -.
DR PaxDb; Q8N3X6; -.
DR PeptideAtlas; Q8N3X6; -.
DR PRIDE; Q8N3X6; -.
DR ProteomicsDB; 71844; -. [Q8N3X6-1]
DR ProteomicsDB; 71845; -. [Q8N3X6-2]
DR ProteomicsDB; 71846; -. [Q8N3X6-3]
DR Antibodypedia; 23115; 138 antibodies from 23 providers.
DR DNASU; 254251; -.
DR Ensembl; ENST00000326877.8; ENSP00000317566.3; ENSG00000178177.16. [Q8N3X6-3]
DR Ensembl; ENST00000382226.5; ENSP00000371661.5; ENSG00000178177.16. [Q8N3X6-1]
DR GeneID; 254251; -.
DR KEGG; hsa:254251; -.
DR UCSC; uc003gpq.4; human. [Q8N3X6-1]
DR CTD; 254251; -.
DR DisGeNET; 254251; -.
DR GeneCards; LCORL; -.
DR HGNC; HGNC:30776; LCORL.
DR HPA; ENSG00000178177; Low tissue specificity.
DR MIM; 611799; gene.
DR neXtProt; NX_Q8N3X6; -.
DR OpenTargets; ENSG00000178177; -.
DR PharmGKB; PA145148507; -.
DR VEuPathDB; HostDB:ENSG00000178177; -.
DR eggNOG; KOG4565; Eukaryota.
DR GeneTree; ENSGT00940000154965; -.
DR HOGENOM; CLU_076618_1_0_1; -.
DR InParanoid; Q8N3X6; -.
DR OMA; CKNSKPV; -.
DR OrthoDB; 47456at2759; -.
DR PhylomeDB; Q8N3X6; -.
DR TreeFam; TF319589; -.
DR PathwayCommons; Q8N3X6; -.
DR SignaLink; Q8N3X6; -.
DR BioGRID-ORCS; 254251; 6 hits in 1100 CRISPR screens.
DR ChiTaRS; LCORL; human.
DR GenomeRNAi; 254251; -.
DR Pharos; Q8N3X6; Tbio.
DR PRO; PR:Q8N3X6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N3X6; protein.
DR Bgee; ENSG00000178177; Expressed in buccal mucosa cell and 182 other tissues.
DR ExpressionAtlas; Q8N3X6; baseline and differential.
DR Genevisible; Q8N3X6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:1990226; F:histone methyltransferase binding; IPI:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF05225; HTH_psq; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Isopeptide bond; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..602
FT /note="Ligand-dependent nuclear receptor corepressor-like
FT protein"
FT /id="PRO_0000310463"
FT DOMAIN 516..568
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 544..564
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 104..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 242
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 319
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 340
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 397
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..389
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029287"
FT VAR_SEQ 260..318
FT /note="RLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYGIPQKTLLLH
FT LEALPAG -> MLQVKTDEKLNVSDENTASCPLSPIKMCLNRPIEWNLNLTTASLTSCT
FT VHNQNLKSEEK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029288"
FT VAR_SEQ 319..602
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029289"
FT CONFLICT 407
FT /note="N -> S (in Ref. 1; BAB70892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 602 AA; 66964 MW; 05245F999E5A61D7 CRC64;
MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC VGFESILEGL
YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS DCIPSLDSSQ STPTEELSSQ
GQSNTDKIEC QAENYLNALF RKKDLPQNCD PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ
ENRNGSIGPS IVCKSIQMNQ AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS
IKSEESSICD PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL
YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA LWARAQAERT
EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES LQYETSNPTV QLKIPQLRVS
SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA LQKLKNILPK QNKIECSGPV THSSVDSYFL
HGDLSPLCLN SKNGTVDGTS ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG
KMSVSKAQGI YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK
PV
