LCORL_MOUSE
ID LCORL_MOUSE Reviewed; 600 AA.
AC Q3U285; B2RRS7; Q6NZG1; Q8BNH5; Q8BRN7; Q8BRT8; Q8C9J6; Q8CJG4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Ligand-dependent nuclear receptor corepressor-like protein;
DE Short=LCoR-like protein;
DE AltName: Full=Mblk1-related protein 1;
DE AltName: Full=Transcription factor MLR1;
GN Name=Lcorl; Synonyms=Mlr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=12560079; DOI=10.1016/s0014-5793(02)03858-9;
RA Kunieda T., Park J.-M., Takeuchi H., Kubo T.;
RT "Identification and characterization of Mlr1,2: two mouse homologues of
RT Mblk-1, a transcription factor from the honeybee brain.";
RL FEBS Lett. 535:61-65(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Brain cortex, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 6-600 (ISOFORM 4).
RC STRAIN=CD-1; TISSUE=Brain, and Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as transcription activator that binds DNA elements
CC with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in
CC spermatogenesis. {ECO:0000269|PubMed:12560079}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q3U285-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3U285-2; Sequence=VSP_029291;
CC Name=3;
CC IsoId=Q3U285-3; Sequence=VSP_029296, VSP_029297;
CC Name=4;
CC IsoId=Q3U285-6; Sequence=VSP_029294, VSP_029295;
CC Name=5;
CC IsoId=Q3U285-5; Sequence=VSP_029292, VSP_029293;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the spermatocytes of the
CC testis. Also found in the kidney, liver and heart.
CC {ECO:0000269|PubMed:12560079}.
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DR EMBL; AB076078; BAC20954.1; -; mRNA.
DR EMBL; AK043498; BAC31560.1; -; mRNA.
DR EMBL; AK043845; BAC31678.1; -; mRNA.
DR EMBL; AK041987; BAC31123.1; -; mRNA.
DR EMBL; AK083689; BAC38994.1; -; mRNA.
DR EMBL; AK154398; BAE32559.1; -; mRNA.
DR EMBL; AK155421; BAE33257.1; -; mRNA.
DR EMBL; BC066151; AAH66151.1; -; mRNA.
DR EMBL; BC138563; AAI38564.1; -; mRNA.
DR CCDS; CCDS19277.1; -. [Q3U285-3]
DR CCDS; CCDS19278.1; -. [Q3U285-2]
DR CCDS; CCDS51499.1; -. [Q3U285-1]
DR RefSeq; NP_001156545.1; NM_001163073.1. [Q3U285-1]
DR RefSeq; NP_742165.1; NM_172153.3. [Q3U285-2]
DR RefSeq; NP_835278.2; NM_178142.5. [Q3U285-3]
DR RefSeq; XP_006503888.1; XM_006503825.3.
DR AlphaFoldDB; Q3U285; -.
DR SMR; Q3U285; -.
DR BioGRID; 229104; 1.
DR STRING; 10090.ENSMUSP00000016026; -.
DR iPTMnet; Q3U285; -.
DR PhosphoSitePlus; Q3U285; -.
DR MaxQB; Q3U285; -.
DR PaxDb; Q3U285; -.
DR PeptideAtlas; Q3U285; -.
DR PRIDE; Q3U285; -.
DR ProteomicsDB; 290013; -. [Q3U285-1]
DR ProteomicsDB; 290014; -. [Q3U285-2]
DR ProteomicsDB; 290015; -. [Q3U285-3]
DR ProteomicsDB; 290016; -. [Q3U285-6]
DR ProteomicsDB; 290017; -. [Q3U285-5]
DR Antibodypedia; 23115; 138 antibodies from 23 providers.
DR DNASU; 209707; -.
DR Ensembl; ENSMUST00000016026; ENSMUSP00000016026; ENSMUSG00000015882. [Q3U285-1]
DR Ensembl; ENSMUST00000045586; ENSMUSP00000042677; ENSMUSG00000015882. [Q3U285-3]
DR Ensembl; ENSMUST00000087164; ENSMUSP00000084408; ENSMUSG00000015882. [Q3U285-2]
DR GeneID; 209707; -.
DR KEGG; mmu:209707; -.
DR UCSC; uc008xjh.3; mouse. [Q3U285-3]
DR UCSC; uc008xji.3; mouse. [Q3U285-6]
DR UCSC; uc008xjk.2; mouse. [Q3U285-1]
DR CTD; 254251; -.
DR MGI; MGI:2651932; Lcorl.
DR VEuPathDB; HostDB:ENSMUSG00000015882; -.
DR eggNOG; KOG4565; Eukaryota.
DR GeneTree; ENSGT00940000154965; -.
DR HOGENOM; CLU_076618_1_0_1; -.
DR InParanoid; Q3U285; -.
DR OMA; CKNSKPV; -.
DR PhylomeDB; Q3U285; -.
DR TreeFam; TF319589; -.
DR BioGRID-ORCS; 209707; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Lcorl; mouse.
DR PRO; PR:Q3U285; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3U285; protein.
DR Bgee; ENSMUSG00000015882; Expressed in ventromedial nucleus of hypothalamus and 246 other tissues.
DR ExpressionAtlas; Q3U285; baseline and differential.
DR Genevisible; Q3U285; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:1990226; F:histone methyltransferase binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:MGI.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR Pfam; PF05225; HTH_psq; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Isopeptide bond; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..600
FT /note="Ligand-dependent nuclear receptor corepressor-like
FT protein"
FT /id="PRO_0000310464"
FT DOMAIN 515..567
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DNA_BIND 543..563
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT REGION 103..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 241
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N3X6"
FT CROSSLNK 318
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N3X6"
FT CROSSLNK 339
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N3X6"
FT CROSSLNK 396
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N3X6"
FT VAR_SEQ 1..83
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12560079"
FT /id="VSP_029291"
FT VAR_SEQ 143..164
FT /note="DLPQNCDPNIPLVAQELMKKMI -> ADSSIWVFKRSPTNSWVSVVGY (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029292"
FT VAR_SEQ 165..600
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029293"
FT VAR_SEQ 227..230
FT /note="GDGV -> ACYK (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029294"
FT VAR_SEQ 231..600
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029295"
FT VAR_SEQ 259..315
FT /note="RLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYGIPQKTLLLH
FT LEALP -> MLQMKTDEKVDLSDGNTASCPLSPIKMCLNHPIEWNLTAASLASCTVHNQ
FT NLKSEEN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029296"
FT VAR_SEQ 316..600
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029297"
FT CONFLICT 18..21
FT /note="Missing (in Ref. 3; AAH66151)"
FT /evidence="ECO:0000305"
FT CONFLICT Q3U285-3:315
FT /note="N -> D (in Ref. 2; BAC31678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 600 AA; 66695 MW; F87DEC6D049B51B2 CRC64;
MDKGRERMAA AAAAAAAAAA AQCRSPRCAA ERRGFRRELD SWRHRLMHCV GFESILEGLY
GPRLRRDLSL FEDCEPEELT DWSMDEKCSF CNLQREAVSD CIPSLDSSQS TPTEELSSQG
QSHTDKIECQ AESYLNALFR KKDLPQNCDP NIPLVAQELM KKMIRQFAIE YISKSGKIQE
NRNGSIGASL VCKSIQMNQA DNCLQDEQEG PLDLTVTRTQ EQTAQQGDGV LDLSTKKTSI
KSEESSISDP SSENAVAGRL HRNREDYVER SAEFADGLLS KALKDIQSGA LDINKAGILY
GIPQKTLLLH LEALPAGKPA SFKNKTRDFN DSYSYNESKE TCAVLQKVAL WARAQTERTE
KSKLNLLETS EFKFPTASSY LHQLTLQKMV TQFKEKNESL QYETSNPPVQ LKIPQLRVNS
VSKSQADGSG LLDVMYQVSK TSSVLEGSAL QKLKNILPKQ NKLDCSGPVT HSSVDSYFLH
GDLSPLCLNS KNGTVDGTSE NTEDGLDRKD NKQPRKKRGR YRQYDHEIME EAIAMVMSGK
MSVSKAQGIY GVPHSTLEYK VKERSGTLKT PPKKKLRLPD TGLYMTDSGT GSCRNSSKPV
