LCP1_DROME
ID LCP1_DROME Reviewed; 130 AA.
AC P02839; Q24290; Q9V4S9;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2001, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Larval cuticle protein 1;
DE AltName: Full=Larval cuticle protein I;
DE Flags: Precursor;
GN Name=Lcp1; ORFNames=CG11650;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=Canton-S, and Oregon-R; TISSUE=Larva;
RX PubMed=6817923; DOI=10.1016/0092-8674(82)90466-4;
RA Snyder M., Hunkapiller M., Yuen D., Silvert D., Fristrom J., Davidson N.;
RT "Cuticle protein genes of Drosophila: structure, organization and evolution
RT of four clustered genes.";
RL Cell 29:1027-1040(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Component of the larval cuticle.
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DR EMBL; V00202; CAA23487.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF59096.1; -; Genomic_DNA.
DR PIR; A03328; UCFF1L.
DR PIR; A25299; A25299.
DR RefSeq; NP_001260801.1; NM_001273872.2.
DR RefSeq; NP_476619.1; NM_057271.4.
DR AlphaFoldDB; P02839; -.
DR BioGRID; 61670; 7.
DR DIP; DIP-18177N; -.
DR IntAct; P02839; 1.
DR STRING; 7227.FBpp0305735; -.
DR PaxDb; P02839; -.
DR DNASU; 35817; -.
DR EnsemblMetazoa; FBtr0088763; FBpp0087841; FBgn0002531.
DR EnsemblMetazoa; FBtr0333557; FBpp0305735; FBgn0002531.
DR GeneID; 35817; -.
DR KEGG; dme:Dmel_CG11650; -.
DR CTD; 3936; -.
DR FlyBase; FBgn0002531; Lcp1.
DR VEuPathDB; VectorBase:FBgn0002531; -.
DR eggNOG; ENOG502TD3C; Eukaryota.
DR GeneTree; ENSGT00900000141325; -.
DR HOGENOM; CLU_065450_3_1_1; -.
DR InParanoid; P02839; -.
DR OMA; HGNIQGK; -.
DR OrthoDB; 1507320at2759; -.
DR PhylomeDB; P02839; -.
DR BioGRID-ORCS; 35817; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35817; -.
DR PRO; PR:P02839; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0002531; Expressed in saliva-secreting gland and 11 other tissues.
DR ExpressionAtlas; P02839; baseline and differential.
DR Genevisible; P02839; DM.
DR GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.
DR GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR GO; GO:0008363; P:larval chitin-based cuticle development; IC:FlyBase.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..16
FT CHAIN 17..130
FT /note="Larval cuticle protein 1"
FT /id="PRO_0000006387"
FT DOMAIN 43..104
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT CONFLICT 37
FT /note="Q -> R (in Ref. 1; CAA23487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 13921 MW; 0A20F5B9D2DC3F4B CRC64;
MFKFVMICAV LGLAVANPPV PHSLGRSEDV HADVLSQSDD VRADGFDSSL HTSNGIEQAA
SGDAHGNIHG NFGWISPEGE HVEVKYVANE NGYQPSGAWI PTPPPIPEAI ARAVAWLESH
PPAPEHPRHH
