LCP1_DROMI
ID LCP1_DROMI Reviewed; 138 AA.
AC P91627; A1BWX7; A1BWX9; A1BWY7; A1BWY9; A1BWZ7; P91628; Q9NCK7; Q9NCK8;
AC Q9NCK9;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Larval cuticle protein 1;
DE AltName: Full=Larval cuticle protein I;
DE Flags: Precursor;
GN Name=Lcp1;
OS Drosophila miranda (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7229;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 17-21.
RX PubMed=8390679; DOI=10.1073/pnas.90.12.5737;
RA Steinemann M., Steinemann S., Lottspeich F.;
RT "How Y chromosomes become genetically inert.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:5737-5741(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8798345; DOI=10.1007/pl00006099;
RA Steinemann M., Steinemann S., Pinsker W.;
RT "Evolution of the larval cuticle proteins coded by the secondary sex
RT chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the
RT DNA sequence level.";
RL J. Mol. Evol. 43:405-412(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=0101.3, 0101.5, 0101.9, MSH22, SP138, and SP235;
RX PubMed=10779531; DOI=10.1093/oxfordjournals.molbev.a026349;
RA Yi S., Charlesworth B.;
RT "Contrasting patterns of molecular evolution of the genes on the new and
RT old sex chromosomes of Drosophila miranda.";
RL Mol. Biol. Evol. 17:703-717(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MA28, MA32, MSH22, MSH38,
RC SP138, SP235, and SP295;
RX PubMed=16547107; DOI=10.1534/genetics.105.054585;
RA Bartolome C., Charlesworth B.;
RT "Rates and patterns of chromosomal evolution in Drosophila pseudoobscura
RT and D. miranda.";
RL Genetics 173:779-791(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MA28, MA32, MSH22, MSH38,
RC SP138, SP235, and SP295;
RX PubMed=17028318; DOI=10.1534/genetics.106.064113;
RA Bartolome C., Charlesworth B.;
RT "Evolution of amino-acid sequences and codon usage on the Drosophila
RT miranda neo-sex chromosomes.";
RL Genetics 174:2033-2044(2006).
CC -!- FUNCTION: Component of the larval cuticle.
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DR EMBL; X97809; CAA66390.1; -; Genomic_DNA.
DR EMBL; AF219246; AAF74425.1; -; Genomic_DNA.
DR EMBL; AF219247; AAF74426.1; -; Genomic_DNA.
DR EMBL; AF219253; AAF74432.1; -; Genomic_DNA.
DR EMBL; AF219254; AAF74433.1; -; Genomic_DNA.
DR EMBL; AF219255; AAF74434.1; -; Genomic_DNA.
DR EMBL; AF219256; AAF74435.1; -; Genomic_DNA.
DR EMBL; DQ867949; ABJ74489.1; -; Genomic_DNA.
DR EMBL; DQ867950; ABJ74490.1; -; Genomic_DNA.
DR EMBL; DQ867951; ABJ74491.1; -; Genomic_DNA.
DR EMBL; DQ867952; ABJ74492.1; -; Genomic_DNA.
DR EMBL; DQ867953; ABJ74493.1; -; Genomic_DNA.
DR EMBL; DQ867954; ABJ74494.1; -; Genomic_DNA.
DR EMBL; DQ867955; ABJ74495.1; -; Genomic_DNA.
DR EMBL; DQ867956; ABJ74496.1; -; Genomic_DNA.
DR EMBL; DQ867957; ABJ74497.1; -; Genomic_DNA.
DR EMBL; DQ867958; ABJ74498.1; -; Genomic_DNA.
DR EMBL; DQ867959; ABJ74499.1; -; Genomic_DNA.
DR EMBL; DQ867960; ABJ74500.1; -; Genomic_DNA.
DR EMBL; DQ867961; ABJ74501.1; -; Genomic_DNA.
DR EMBL; DQ867962; ABJ74502.1; -; Genomic_DNA.
DR EMBL; DQ867963; ABJ74503.1; -; Genomic_DNA.
DR EMBL; DQ867964; ABJ74504.1; -; Genomic_DNA.
DR EMBL; DQ867965; ABJ74505.1; -; Genomic_DNA.
DR EMBL; DQ867966; ABJ74506.1; -; Genomic_DNA.
DR EMBL; DQ867967; ABJ74507.1; -; Genomic_DNA.
DR EMBL; DQ867968; ABJ74508.1; -; Genomic_DNA.
DR EMBL; DQ867969; ABJ74509.1; -; Genomic_DNA.
DR EMBL; DQ867970; ABJ74510.1; -; Genomic_DNA.
DR EMBL; DQ867971; ABJ74511.1; -; Genomic_DNA.
DR EMBL; DQ867972; ABJ74512.1; -; Genomic_DNA.
DR RefSeq; XP_017150715.1; XM_017295226.1.
DR AlphaFoldDB; P91627; -.
DR GeneID; 108160938; -.
DR KEGG; dmn:108160938; -.
DR FlyBase; FBgn0013843; Dmir\Lcp1.
DR OMA; HGNIQGK; -.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:8390679"
FT CHAIN 17..138
FT /note="Larval cuticle protein 1"
FT /id="PRO_0000006388"
FT DOMAIN 49..110
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT VARIANT 13
FT /note="V -> L (in strain: 0101.3, 0101.4, 0101.5, 0101.7,
FT 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295)"
FT VARIANT 29
FT /note="P -> Q (in strain: 0101.3, 0101.4, 0101.5, 0101.7,
FT 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295)"
FT VARIANT 47
FT /note="V -> I (in strain: 0101.3, 0101.4, 0101.5, 0101.7,
FT 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295)"
FT VARIANT 52
FT /note="F -> Y (in strain: SP235)"
FT VARIANT 53
FT /note="D -> H (in strain: 0101.5)"
FT VARIANT 56
FT /note="L -> F (in strain: MSH22)"
FT VARIANT 129
FT /note="A -> V (in strain: 0101.3, 0101.4, 0101.5, 0101.7,
FT 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295)"
SQ SEQUENCE 138 AA; 14746 MW; D2641B0F51B05D2D CRC64;
MFKFVMVFAV LGVAAAGVAH VPHPQVSHPV GRSEDVHAEV KSEHSDVRAD GFDADLLVSN
SIQQASSGDV HGNIHGSFSW ISPEGEHVEI KYVADENGYQ PVGAVLPTPP PIPEAIARAV
AWLEAHPQAP EPVHHSHH
