ID   LCP2A_DROME             Reviewed;         117 AA.
AC   Q7JZV0; P82383;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Cuticular protein 47Eg;
DE   AltName: Full=Larval cuticle protein 2A;
DE   Flags: Precursor;
GN   Name=Cpr47Eg; Synonyms=Lcp2a; ORFNames=CG9070;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3] {ECO:0000312|EMBL:AAL48636.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAL48636.1};
RC   TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 17-26, AND FUNCTION.
RC   STRAIN=Oregon-R {ECO:0000269|Ref.4}; TISSUE=Larva {ECO:0000269|Ref.4};
RA   Chihara C.J.;
RT   "Third instar cuticle proteins.";
RL   Submitted (MAY-2000) to UniProtKB.
CC   -!- FUNCTION: Component of the larval cuticle. {ECO:0000269|Ref.4}.
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DR   EMBL; AE013599; AAF58686.1; -; Genomic_DNA.
DR   EMBL; AY071014; AAL48636.1; -; mRNA.
DR   RefSeq; NP_610661.1; NM_136817.4.
DR   AlphaFoldDB; Q7JZV0; -.
DR   BioGRID; 61992; 3.
DR   IntAct; Q7JZV0; 1.
DR   STRING; 7227.FBpp0087279; -.
DR   PaxDb; Q7JZV0; -.
DR   DNASU; 36196; -.
DR   EnsemblMetazoa; FBtr0088183; FBpp0087279; FBgn0086519.
DR   GeneID; 36196; -.
DR   KEGG; dme:Dmel_CG9070; -.
DR   CTD; 36196; -.
DR   FlyBase; FBgn0086519; Cpr47Eg.
DR   VEuPathDB; VectorBase:FBgn0086519; -.
DR   eggNOG; ENOG502T7XA; Eukaryota.
DR   GeneTree; ENSGT00940000166531; -.
DR   HOGENOM; CLU_065450_3_1_1; -.
DR   InParanoid; Q7JZV0; -.
DR   OMA; QQGEQWV; -.
DR   OrthoDB; 1459720at2759; -.
DR   PhylomeDB; Q7JZV0; -.
DR   BioGRID-ORCS; 36196; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 36196; -.
DR   PRO; PR:Q7JZV0; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0086519; Expressed in larva and 12 other tissues.
DR   ExpressionAtlas; Q7JZV0; baseline and differential.
DR   Genevisible; Q7JZV0; DM.
DR   GO; GO:0062129; C:chitin-based extracellular matrix; ISM:FlyBase.
DR   GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; ISM:FlyBase.
DR   GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR   InterPro; IPR031305; Casein_CS.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|Ref.4"
FT   CHAIN           17..117
FT                   /note="Cuticular protein 47Eg"
FT                   /id="PRO_0000260042"
FT   DOMAIN          31..97
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
FT   CONFLICT        18
FT                   /note="E -> V (in Ref. 4; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   117 AA;  12680 MW;  9184376740F9AF9D CRC64;
     MKFFIAFACL LAVALANEDA NVLRAEQQVN VDGFAYAVEL DNSVNVQQKG DLNGEEWVVK
     GSQSWTSPEN VPVSIQYIAD ANGYQVVSAN PPLPTPPPIP EAIQRSLEYI AAHPPSQ