LCP2_DROME
ID LCP2_DROME Reviewed; 126 AA.
AC P07187; C0HBT8; Q9V4T0;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Larval cuticle protein 2;
DE AltName: Full=Larval cuticle protein II;
DE Flags: Precursor;
GN Name=Lcp2; ORFNames=CG8697;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=Canton-S, and Oregon-R; TISSUE=Larva;
RX PubMed=6817923; DOI=10.1016/0092-8674(82)90466-4;
RA Snyder M., Hunkapiller M., Yuen D., Silvert D., Fristrom J., Davidson N.;
RT "Cuticle protein genes of Drosophila: structure, organization and evolution
RT of four clustered genes.";
RL Cell 29:1027-1040(1982).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the larval cuticle.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACN12154.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; V00203; CAA23488.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF59095.2; -; Genomic_DNA.
DR EMBL; BT059794; ACN12154.1; ALT_INIT; mRNA.
DR PIR; B25299; B25299.
DR RefSeq; NP_001260802.1; NM_001273873.2.
DR RefSeq; NP_476620.1; NM_057272.4.
DR AlphaFoldDB; P07187; -.
DR BioGRID; 61671; 27.
DR DIP; DIP-18187N; -.
DR IntAct; P07187; 6.
DR STRING; 7227.FBpp0305734; -.
DR PaxDb; P07187; -.
DR DNASU; 35818; -.
DR EnsemblMetazoa; FBtr0088761; FBpp0087840; FBgn0002533.
DR EnsemblMetazoa; FBtr0333556; FBpp0305734; FBgn0002533.
DR GeneID; 35818; -.
DR KEGG; dme:Dmel_CG8697; -.
DR CTD; 3937; -.
DR FlyBase; FBgn0002533; Lcp2.
DR VEuPathDB; VectorBase:FBgn0002533; -.
DR eggNOG; ENOG502T8XY; Eukaryota.
DR GeneTree; ENSGT00900000141325; -.
DR HOGENOM; CLU_065450_3_1_1; -.
DR InParanoid; P07187; -.
DR OMA; QMENVMA; -.
DR OrthoDB; 1507320at2759; -.
DR PhylomeDB; P07187; -.
DR BioGRID-ORCS; 35818; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35818; -.
DR PRO; PR:P07187; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0002533; Expressed in larva and 7 other tissues.
DR ExpressionAtlas; P07187; differential.
DR Genevisible; P07187; DM.
DR GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.
DR GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR GO; GO:0008363; P:larval chitin-based cuticle development; IC:FlyBase.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..16
FT CHAIN 17..126
FT /note="Larval cuticle protein 2"
FT /id="PRO_0000006389"
FT DOMAIN 39..100
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ SEQUENCE 126 AA; 13488 MW; 0246143E069CCE1E CRC64;
MFKFVMILAV VGVATALAPV SRSDDVHADV LSRSDDVRAD GFDSSLHTSN GIEQAASGDA
HGNIHGNFGW ISPEGEHVEV KYVANENGYQ PSGAWIPTPP PIPEAIARAV AWLESHPPAP
EHPRHH
