ID   LCP34_DROMI             Reviewed;         112 AA.
AC   Q01774; P91630;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Larval cuticle protein III/IV;
DE   Flags: Precursor;
GN   Name=Lcp3;
GN   and
GN   Name=Lcp4;
OS   Drosophila miranda (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1323846; DOI=10.1073/pnas.89.16.7591;
RA   Steinemann M., Steinemann S.;
RT   "Degenerating Y chromosome of Drosophila miranda: a trap for
RT   retrotransposons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:7591-7595(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8798345; DOI=10.1007/pl00006099;
RA   Steinemann M., Steinemann S., Pinsker W.;
RT   "Evolution of the larval cuticle proteins coded by the secondary sex
RT   chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the
RT   DNA sequence level.";
RL   J. Mol. Evol. 43:405-412(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 17-21.
RX   PubMed=8390679; DOI=10.1073/pnas.90.12.5737;
RA   Steinemann M., Steinemann S., Lottspeich F.;
RT   "How Y chromosomes become genetically inert.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:5737-5741(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=0101.3, 0101.7, and MSH38;
RX   PubMed=10779531; DOI=10.1093/oxfordjournals.molbev.a026349;
RA   Yi S., Charlesworth B.;
RT   "Contrasting patterns of molecular evolution of the genes on the new and
RT   old sex chromosomes of Drosophila miranda.";
RL   Mol. Biol. Evol. 17:703-717(2000).
CC   -!- FUNCTION: Component of the larval cuticle.
CC   -!- CAUTION: The LCP3 and LCP4 genes on chromosome X code for identical
CC       proteins. There are also pseudogenes for both LCP3 and LCP4 on
CC       chromosome neo-Y. {ECO:0000305}.
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DR   EMBL; M94252; AAA28670.1; -; Genomic_DNA.
DR   EMBL; X97813; CAA66393.1; -; Genomic_DNA.
DR   EMBL; X97815; CAA66395.1; -; Genomic_DNA.
DR   EMBL; AF219248; AAF74427.1; -; Genomic_DNA.
DR   EMBL; AF219249; AAF74428.1; -; Genomic_DNA.
DR   EMBL; AF219250; AAF74429.1; -; Genomic_DNA.
DR   RefSeq; XP_017146012.1; XM_017290523.1.
DR   RefSeq; XP_017146025.1; XM_017290536.1.
DR   AlphaFoldDB; Q01774; -.
DR   GeneID; 108158286; -.
DR   GeneID; 108158295; -.
DR   KEGG; dmn:108158286; -.
DR   KEGG; dmn:108158295; -.
DR   FlyBase; FBgn0013847; Dmir\Lcp3.
DR   FlyBase; FBgn0012555; Dmir\Lcp4.
DR   OMA; YEWISPE; -.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Cuticle; Direct protein sequencing; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:8390679"
FT   CHAIN           17..112
FT                   /note="Larval cuticle protein III/IV"
FT                   /id="PRO_0000006392"
FT   DOMAIN          31..92
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ   SEQUENCE   112 AA;  11880 MW;  7F40D114E3FF4871 CRC64;
     MFKILLVCAL AALVAANENA EVKELVNEVN PDGFKTVVSL SDGSASQASG DVHGNIDGVF
     EWVSPEGVHV RVAYKADENG YQPSSDLLPV APPIPEAILK SLAWIEAHPS KE