ID   LCP4_DROME              Reviewed;         112 AA.
AC   P07189; D0IQD9; Q9V4T2;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Larval cuticle protein 4;
DE   AltName: Full=Larval cuticle protein IV;
DE   Flags: Precursor;
GN   Name=Lcp4; ORFNames=CG2044;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=Canton-S, and Oregon-R; TISSUE=Larva;
RX   PubMed=6817923; DOI=10.1016/0092-8674(82)90466-4;
RA   Snyder M., Hunkapiller M., Yuen D., Silvert D., Fristrom J., Davidson N.;
RT   "Cuticle protein genes of Drosophila: structure, organization and evolution
RT   of four clustered genes.";
RL   Cell 29:1027-1040(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Carlson J.W., Booth B., Frise E., Sandler J., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the larval cuticle.
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DR   EMBL; V00203; CAA23490.1; -; Genomic_DNA.
DR   EMBL; AE013599; AAF59093.1; -; Genomic_DNA.
DR   EMBL; BT100177; ACY30634.1; -; mRNA.
DR   PIR; D25299; D25299.
DR   RefSeq; NP_001260804.1; NM_001273875.1.
DR   RefSeq; NP_476622.1; NM_057274.4.
DR   AlphaFoldDB; P07189; -.
DR   BioGRID; 61673; 1.
DR   IntAct; P07189; 2.
DR   STRING; 7227.FBpp0087823; -.
DR   PaxDb; P07189; -.
DR   DNASU; 35820; -.
DR   EnsemblMetazoa; FBtr0088744; FBpp0087823; FBgn0002535.
DR   EnsemblMetazoa; FBtr0333555; FBpp0305733; FBgn0002535.
DR   GeneID; 35820; -.
DR   KEGG; dme:Dmel_CG2044; -.
DR   CTD; 35820; -.
DR   FlyBase; FBgn0002535; Lcp4.
DR   VEuPathDB; VectorBase:FBgn0002535; -.
DR   eggNOG; ENOG502TD3C; Eukaryota.
DR   GeneTree; ENSGT00900000141325; -.
DR   HOGENOM; CLU_065450_3_1_1; -.
DR   InParanoid; P07189; -.
DR   OMA; YEWISPE; -.
DR   OrthoDB; 1459720at2759; -.
DR   PhylomeDB; P07189; -.
DR   BioGRID-ORCS; 35820; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Lcp4; fly.
DR   GenomeRNAi; 35820; -.
DR   PRO; PR:P07189; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0002535; Expressed in larva and 12 other tissues.
DR   ExpressionAtlas; P07189; baseline and differential.
DR   Genevisible; P07189; DM.
DR   GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
DR   GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.
DR   GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR   InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR   InterPro; IPR000618; Insect_cuticle.
DR   Pfam; PF00379; Chitin_bind_4; 1.
DR   PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR   PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE   1: Evidence at protein level;
KW   Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT   SIGNAL          1..16
FT   CHAIN           17..112
FT                   /note="Larval cuticle protein 4"
FT                   /id="PRO_0000006393"
FT   DOMAIN          31..92
FT                   /note="Chitin-binding type R&R"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ   SEQUENCE   112 AA;  11980 MW;  FE2AC596EC8BFEDB CRC64;
     MFKILLVCAL VALVAANENP EVKELVNDVQ ADGFVSKLVL DNGSAASATG DVHGNIDGVF
     EWVSPEGEHV RVSYKADENG YQPQSDLLPT PPPIPEAILK AIAYIQAHPS KE