LCP52_DROME
ID LCP52_DROME Reviewed; 104 AA.
AC C0HL63; O96905; P92192;
DT 18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT 18-JUL-2018, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=Larval cuticle protein 65Ab2 {ECO:0000303|PubMed:9383064};
DE AltName: Full=Larval cuticle protein 5 {ECO:0000303|PubMed:9383064};
DE Flags: Precursor;
GN Name=Lcp65Ab2 {ECO:0000303|PubMed:9383064,
GN ECO:0000312|FlyBase:FBgn0020643};
GN Synonyms=Lcp-b2 {ECO:0000303|PubMed:9654737},
GN Lcp5 {ECO:0000303|PubMed:9383064};
GN ORFNames=CG18773 {ECO:0000312|FlyBase:FBgn0020643};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Iso-1;
RX PubMed=9383064; DOI=10.1093/genetics/147.3.1213;
RA Charles J.-P., Chihara C., Nejad S., Riddiford L.M.;
RT "A cluster of cuticle genes of Drosophila at 65A: sequence, structure and
RT evolution.";
RL Genetics 147:1213-1224(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PROTEIN SEQUENCE OF 19-32, FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R; TISSUE=Larva;
RX PubMed=9654737; DOI=10.1016/s0965-1748(97)00107-0;
RA Charles J.-P., Chihara C., Nejad S., Riddiford L.M.;
RT "Identification of proteins and developmental expression of RNAs encoded by
RT the 65A cuticle protein gene cluster in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 28:131-138(1998).
CC -!- FUNCTION: Component of the cuticle of the larva.
CC {ECO:0000269|PubMed:9654737}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at the end of second larval
CC instar, present throughout third larval instar and is gone by the pupal
CC stages. {ECO:0000269|PubMed:9654737}.
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DR EMBL; U84746; AAB88065.1; -; Genomic_DNA.
DR EMBL; AE014296; AAG22328.1; -; Genomic_DNA.
DR EMBL; AY071366; AAL48988.1; -; mRNA.
DR RefSeq; NP_524814.2; NM_080075.3.
DR RefSeq; NP_788469.1; NM_176291.3.
DR AlphaFoldDB; C0HL63; -.
DR DNASU; 48382; -.
DR EnsemblMetazoa; FBtr0076992; FBpp0076701; FBgn0020643.
DR EnsemblMetazoa; FBtr0076994; FBpp0076702; FBgn0020644.
DR GeneID; 48381; -.
DR GeneID; 48382; -.
DR KEGG; dme:Dmel_CG18773; -.
DR KEGG; dme:Dmel_CG32400; -.
DR CTD; 48381; -.
DR CTD; 48382; -.
DR FlyBase; FBgn0020643; Lcp65Ab2.
DR VEuPathDB; VectorBase:FBgn0020643; -.
DR VEuPathDB; VectorBase:FBgn0020644; -.
DR PRO; PR:C0HL63; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0020643; Expressed in larva and 4 other tissues.
DR GO; GO:0062129; C:chitin-based extracellular matrix; IDA:FlyBase.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; IDA:FlyBase.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:9654737"
FT CHAIN 19..104
FT /note="Larval cuticle protein 65Ab2"
FT /id="PRO_0000444631"
FT DOMAIN 32..102
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ SEQUENCE 104 AA; 11267 MW; BA60DD9483DD6992 CRC64;
MKFLIVFVAL FAMAVARPNL AEIVRQVSDV EPEKWSSDVE TSDGTSIKQE GVLKNAGTDN
EAAVVHGSFT WVDEKTGEKF TITYVADENG YQPQGAHLPV APVA
