LCP82_DROME
ID LCP82_DROME Reviewed; 105 AA.
AC C0HL65; P92201;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 1.
DT 03-AUG-2022, entry version 19.
DE RecName: Full=Larval cuticle protein 65Ag2 {ECO:0000312|FlyBase:FBgn0020637};
DE AltName: Full=Larval cuticle protein 8 {ECO:0000303|PubMed:9383064};
DE Flags: Precursor;
GN Name=Lcp65Ag2 {ECO:0000312|FlyBase:FBgn0020637};
GN Synonyms=Lcp-g2 {ECO:0000303|PubMed:9383064},
GN Lcp8 {ECO:0000303|PubMed:9383064};
GN ORFNames=CG10534 {ECO:0000312|FlyBase:FBgn0020637};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Iso-1;
RX PubMed=9383064; DOI=10.1093/genetics/147.3.1213;
RA Charles J.-P., Chihara C., Nejad S., Riddiford L.M.;
RT "A cluster of cuticle genes of Drosophila at 65A: sequence, structure and
RT evolution.";
RL Genetics 147:1213-1224(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP PROTEIN SEQUENCE OF 19-28, FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R; TISSUE=Larva;
RX PubMed=9654737; DOI=10.1016/s0965-1748(97)00107-0;
RA Charles J.-P., Chihara C., Nejad S., Riddiford L.M.;
RT "Identification of proteins and developmental expression of RNAs encoded by
RT the 65A cuticle protein gene cluster in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 28:131-138(1998).
CC -!- FUNCTION: Component of the cuticle of the larva.
CC {ECO:0000269|PubMed:9654737}.
CC -!- DEVELOPMENTAL STAGE: Expression begins in late embryo and end late
CC third larval instar. Maximal expression is at the end of the first
CC larval instar. {ECO:0000269|PubMed:9654737}.
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DR EMBL; U84754; AAB88072.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50693.1; -; Genomic_DNA.
DR RefSeq; NP_477272.1; NM_057924.3.
DR RefSeq; NP_477273.1; NM_057925.3.
DR AlphaFoldDB; C0HL65; -.
DR DNASU; 38703; -.
DR EnsemblMetazoa; FBtr0077058; FBpp0076766; FBgn0020638.
DR EnsemblMetazoa; FBtr0077059; FBpp0076767; FBgn0020637.
DR GeneID; 38702; -.
DR GeneID; 38703; -.
DR KEGG; dme:Dmel_CG10530; -.
DR KEGG; dme:Dmel_CG10534; -.
DR CTD; 38702; -.
DR CTD; 38703; -.
DR FlyBase; FBgn0020637; Lcp65Ag2.
DR VEuPathDB; VectorBase:FBgn0020637; -.
DR VEuPathDB; VectorBase:FBgn0020638; -.
DR ChiTaRS; Lcp65Ag2; fly.
DR PRO; PR:C0HL65; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0020637; Expressed in mouthpart and 12 other tissues.
DR ExpressionAtlas; C0HL65; baseline and differential.
DR GO; GO:0062129; C:chitin-based extracellular matrix; ISM:FlyBase.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; ISM:FlyBase.
DR GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PRINTS; PR00947; CUTICLE.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:9654737"
FT CHAIN 19..105
FT /note="Larval cuticle protein 65Ag2"
FT /id="PRO_0000443304"
FT DOMAIN 34..103
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ SEQUENCE 105 AA; 11194 MW; F23DA9A5BAB21D2F CRC64;
MKFLIVFVAL FAVALAAPAA EEPTIVRSES DVGPESFKYD WETSDGQAAQ AVGQLNDIGT
ENEAISVSGS YRFIADDGQT YQVNYIADKN GFQPQGAHLP VAPVA
