LCP9_DROME
ID LCP9_DROME Reviewed; 92 AA.
AC P82384; Q9W109;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Larval cuticle protein 9;
DE AltName: Full=Larval cuticle protein IX;
DE Flags: Precursor;
GN Name=Lcp9; ORFNames=CG16914;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP PROTEIN SEQUENCE OF 17-26.
RC STRAIN=Oregon-R; TISSUE=Larva;
RX PubMed=9654737; DOI=10.1016/s0965-1748(97)00107-0;
RA Charles J.-P., Chihara C., Nejad S., Riddiford L.M.;
RT "Identification of proteins and developmental expression of RNAs encoded by
RT the 65A cuticle protein gene cluster in Drosophila melanogaster.";
RL Insect Biochem. Mol. Biol. 28:131-138(1998).
CC -!- FUNCTION: Component of the cuticle of the larva. {ECO:0000305}.
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DR EMBL; AE013599; AAF47269.1; -; Genomic_DNA.
DR RefSeq; NP_523854.1; NM_079130.2.
DR AlphaFoldDB; P82384; -.
DR STRING; 7227.FBpp0072335; -.
DR PaxDb; P82384; -.
DR DNASU; 37963; -.
DR EnsemblMetazoa; FBtr0072430; FBpp0072335; FBgn0025578.
DR GeneID; 37963; -.
DR KEGG; dme:Dmel_CG16914; -.
DR CTD; 37963; -.
DR FlyBase; FBgn0025578; Lcp9.
DR VEuPathDB; VectorBase:FBgn0025578; -.
DR eggNOG; ENOG502TCUU; Eukaryota.
DR HOGENOM; CLU_065450_7_2_1; -.
DR InParanoid; P82384; -.
DR OMA; EYNEVNP; -.
DR OrthoDB; 1526020at2759; -.
DR PhylomeDB; P82384; -.
DR BioGRID-ORCS; 37963; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Lcp9; fly.
DR GenomeRNAi; 37963; -.
DR PRO; PR:P82384; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0025578; Expressed in larva and 6 other tissues.
DR ExpressionAtlas; P82384; baseline and differential.
DR Genevisible; P82384; DM.
DR GO; GO:0062129; C:chitin-based extracellular matrix; ISM:FlyBase.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0008010; F:structural constituent of chitin-based larval cuticle; ISM:FlyBase.
DR GO; GO:0040003; P:chitin-based cuticle development; ISM:FlyBase.
DR GO; GO:0008363; P:larval chitin-based cuticle development; NAS:UniProtKB.
DR InterPro; IPR031311; CHIT_BIND_RR_consensus.
DR InterPro; IPR000618; Insect_cuticle.
DR Pfam; PF00379; Chitin_bind_4; 1.
DR PRINTS; PR00947; CUTICLE.
DR PROSITE; PS00233; CHIT_BIND_RR_1; 1.
DR PROSITE; PS51155; CHIT_BIND_RR_2; 1.
PE 1: Evidence at protein level;
KW Cuticle; Direct protein sequencing; Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:9654737"
FT CHAIN 17..92
FT /note="Larval cuticle protein 9"
FT /id="PRO_0000006396"
FT DOMAIN 31..92
FT /note="Chitin-binding type R&R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00497"
SQ SEQUENCE 92 AA; 10237 MW; D661B07B7387DDC8 CRC64;
MKFVIVLACL LAVVFANEEA DVVKSDSEVN LLDFNYAYEL SNHIRAVQTG ALKEHDNWVV
SGEYEYVAPN GKTVKVVYTA DETGYHPKVV EA
