ID   LCPB_CORGL              Reviewed;         414 AA.
AC   Q8NLN8;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Probable cell wall biosynthesis protein LcpB {ECO:0000305};
GN   Name=lcpB {ECO:0000303|PubMed:27551018};
GN   OrderedLocusNames=Cgl2902 {ECO:0000312|EMBL:BAC00296.1};
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=24377418; DOI=10.1186/1741-7007-11-122;
RA   Baumgart M., Luder K., Grover S., Gaetgens C., Besra G.S., Frunzke J.;
RT   "IpsA, a novel LacI-type regulator, is required for inositol-derived lipid
RT   formation in Corynebacteria and Mycobacteria.";
RL   BMC Biol. 11:122-122(2013).
RN   [3]
RP   SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=27551018; DOI=10.1128/jb.00406-16;
RA   Baumgart M., Schubert K., Bramkamp M., Frunzke J.;
RT   "Impact of LytR-CpsA-Psr proteins on cell wall biosynthesis in
RT   Corynebacterium glutamicum.";
RL   J. Bacteriol. 198:3045-3059(2016).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:27551018}; Single-pass membrane protein
CC       {ECO:0000255}. Note=Localizes at regions of strong cell wall
CC       biosynthesis, such as the poles and the division plane.
CC       {ECO:0000269|PubMed:27551018}.
CC   -!- INDUCTION: Transcriptionally regulated by IpsA.
CC       {ECO:0000269|PubMed:24377418}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant does not show any growth-related
CC       or morphological phenotype under the tested conditions.
CC       {ECO:0000269|PubMed:27551018}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC00296.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305|PubMed:27551018};
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DR   EMBL; BA000036; BAC00296.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_602092.2; NC_003450.3.
DR   AlphaFoldDB; Q8NLN8; -.
DR   SMR; Q8NLN8; -.
DR   STRING; 196627.cg3210; -.
DR   KEGG; cgl:Cgl2902; -.
DR   PATRIC; fig|196627.13.peg.2832; -.
DR   eggNOG; COG1316; Bacteria.
DR   HOGENOM; CLU_016455_0_1_11; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   2: Evidence at transcript level;
KW   Cell inner membrane; Cell membrane; Cell wall biogenesis/degradation;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..414
FT                   /note="Probable cell wall biosynthesis protein LcpB"
FT                   /id="PRO_0000442347"
FT   TOPO_DOM        1..120
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:27551018"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..414
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305|PubMed:27551018"
FT   REGION          1..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..83
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  44610 MW;  00C85918425BB6B4 CRC64;
     MDSPGQGEIA RDSQGRPILD RYGRPVRVRP QPRQTPPTPR TPPVNETRVY QPRQTPPRQT
     PPRQTPPRQM PPRQTPPRQV PPQQQYQQPG QIGQVRPQPP VIAGDGGRRR KAISFKPRGC
     LGTIAGVLAV GLVLVFVVTL WADSKLNRVD ATPATQVANT AGTNWLLVGS DSRQGLSDED
     IERLGTGGDI GVGRTDTIMV LHMPRTGEPT LLSIPRDSYV NVPGWGMDKA NAAFTVGGPE
     LLTQTVEEAT GLRIDHYAEI GMGGLANMVD AVGGVEMCPA EPMYDPLANL DIQAGCQEFD
     GAAALGYVRT RATALGDLDR VVRQREFFSA LLSTATSPGT LLNPFRTFPM ISNAVGTFTV
     GEGDHVWHLA RLALAMRGGI VTETVPIASF ADYDVGNVAI WDEAGAEALF SSMR