ID   LCRD_YERE8              Reviewed;         704 AA.
AC   A1JU76; O68548; P21210; Q84GT4; Q93KU1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Low calcium response locus protein D;
GN   Name=lcrD; OrderedLocusNames=YEP0018;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OG   Plasmid pYVe8081.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11402007; DOI=10.1128/iai.69.7.4627-4638.2001;
RA   Snellings N.J., Popek M., Lindler L.E.;
RT   "Complete DNA sequence of Yersinia enterocolitica serotype 0:8 low-calcium-
RT   response plasmid reveals a new virulence plasmid-associated replicon.";
RL   Infect. Immun. 69:4627-4638(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Could be involved in the secretion of the yop virulence
CC       proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; AF336309; AAK69216.1; -; Genomic_DNA.
DR   EMBL; AM286416; CAL10042.1; -; Genomic_DNA.
DR   RefSeq; NP_863517.1; NC_005017.1.
DR   RefSeq; WP_011117635.1; NC_008791.1.
DR   RefSeq; YP_001004072.1; NC_008791.1.
DR   AlphaFoldDB; A1JU76; -.
DR   SMR; A1JU76; -.
DR   STRING; 393305.YEP0018; -.
DR   EnsemblBacteria; CAL10042; CAL10042; YEP0018.
DR   KEGG; yen:YEP0018; -.
DR   PATRIC; fig|393305.7.peg.21; -.
DR   eggNOG; COG4789; Bacteria.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   OMA; PQFIGLQ; -.
DR   PRO; PR:A1JU76; -.
DR   Proteomes; UP000000642; Plasmid pYVe8081.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   InterPro; IPR006302; T3SS_HrcV.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01399; hrcV; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Plasmid; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..704
FT                   /note="Low calcium response locus protein D"
FT                   /id="PRO_0000285827"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   704 AA;  77844 MW;  B9F748F50B664A85 CRC64;
     MNPYDLEWLN RIGERKDIML AVLLLAVVFM MVLPLPPLVL DILIAVNMTI SVVLLMIAIY
     INSPLQFSAF PAVLLVTTLF RLALSVSTTR MILLQADAGQ IVYTFGNFVV GGNLIVGIVI
     FLIITIVQFL VITKGSERVA EVSARFSLDA MPGKQMSIDG DMRAGVIDVN EARERRATIE
     KESQMFGSMD GAMKFVKGDA IAGLIIIFVN ILGGVTIGVT QKGLAAAEAL QLYSILTVGD
     GMVSQVPALL IAITAGIIVT RVSSEDSSDL GSDIGKQVVA QPKAMLIGGV LLLLFGLIPG
     FPTVTFLILA LLVGCGGYML SRKQSRNDEA NQDLQSLLTS GSGAPAARTK AKTSGANKGR
     LGEQEAFAMT VPLLIDVDSS QQEALEAIAL NDELVRVRRA LYLDLGVPFP GIHLRFNEGM
     GEGEYLISLQ EVPVARGELK AGYLLVRESV SQLELLGIPY EKGEHLLPDQ ETFWVSVEYE
     ERLEKSQLEF FSHSQVLTWH LSHVLREYAE DFIGIQETRY LLEQMEGGYG ELIKEVQRIV
     PLQRMTEILQ RLVGEDISIR NMRSILEAMV EWGQKEKDVV QLTEYIRSSL KRYICYKYAN
     GNNILPAYLF DQEVEEKIRS AVRQTSAGSY LALDPAVTES LLEQVRKTIG DLSQIQSKPV
     LIVSMDIRRY VRKLIESEYY GLPVLSYQEL TQQINIQPLG RVCL