ID   LCRD_YEREN              Reviewed;         704 AA.
AC   P0C2V3; O68548; P21210; Q84GT4; Q93KU1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Low calcium response locus protein D;
GN   Name=lcrD;
OS   Yersinia enterocolitica.
OG   Plasmid pYV, Plasmid pYVe227, and Plasmid pYVa127/90.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51871 / WA-314 / Serotype O:8; PLASMID=pYV;
RA   Roggemkamp A.;
RL   Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W22703 / Serotype O:9 / Biotype 2; PLASMID=pYVe227;
RA   Iriarte M., Lambermont I., Kerbourch C., Cornelis G.R.;
RT   "Detailed genetic map of the pYVe227 plasmid of Yersinia enterocolitica
RT   serotype O:9.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A127/90 / Serotype O:8 / Biotype 1B; PLASMID=pYVa127/90;
RX   PubMed=14527656; DOI=10.1016/s0923-2508(03)00147-5;
RA   Foultier B., Cornelis G.R.;
RT   "DNA sequence and analysis of the pYVa127/90 virulence plasmid of Yersinia
RT   enterocolitica strain A127/90.";
RL   Res. Microbiol. 154:553-557(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-159.
RC   STRAIN=Serotype O:3; PLASMID=pYV;
RX   PubMed=2160939; DOI=10.1128/jb.172.6.3152-3162.1990;
RA   Viitanen A.-M., Toivanen P., Skurnik M.;
RT   "The lcrE gene is part of an operon in the lcr region of Yersinia
RT   enterocolitica O:3.";
RL   J. Bacteriol. 172:3152-3162(1990).
CC   -!- FUNCTION: Could be involved in the secretion of the yop virulence
CC       proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; X67771; CAA47985.1; -; Genomic_DNA.
DR   EMBL; AF102990; AAD16818.1; -; Genomic_DNA.
DR   EMBL; AY150843; AAN37522.1; -; Genomic_DNA.
DR   EMBL; M32097; AAA98433.1; -; Genomic_DNA.
DR   PIR; S25586; S25586.
DR   RefSeq; NP_783668.1; NC_004564.1.
DR   RefSeq; WP_011100753.1; NZ_NWMR01000033.1.
DR   PDB; 7ALW; EM; 3.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-704.
DR   PDBsum; 7ALW; -.
DR   AlphaFoldDB; P0C2V3; -.
DR   SMR; P0C2V3; -.
DR   TCDB; 3.A.6.1.1; the type iii (virulence-related) secretory pathway (iiisp) family.
DR   OrthoDB; 436367at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   InterPro; IPR006302; T3SS_HrcV.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01399; hrcV; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; Membrane; Plasmid;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport;
KW   Virulence.
FT   CHAIN           1..704
FT                   /note="Low calcium response locus protein D"
FT                   /id="PRO_0000190029"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         114
FT                   /note="F -> L (in plasmid pYVe227 and plasmid pYVa127/90)"
FT   VARIANT         337
FT                   /note="L -> I (in plasmid pYVe227)"
FT   VARIANT         621
FT                   /note="G -> R (in plasmid pYVe227)"
SQ   SEQUENCE   704 AA;  77838 MW;  C5B3733BF510B216 CRC64;
     MNPHDLEWLN RIGERKDIML AVLLLAVVFM MVLPLPPLVL DILIAVNMTI SVVLLMIAIY
     INSPLQFSAF PAVLLVTTLF RLALSVSTTR MILLQADAGQ IVYTFGNFVV GGNFIVGIVI
     FLIITIVQFL VITKGSERVA EVSARFSLDA MPGKQMSIDG DMRAGVIDVN EARERRATIE
     KESQMFGSMD GAMKFVKGDA IAGLIIIFVN ILGGVTIGVT QKGLAAAEAL QLYSILTVGD
     GMVSQVPALL IAITAGIIVT RVSSEDSSDL GSDIGKQVVA QPKAMLIGGV LLLLFGLIPG
     FPTVTFLILA LLVGCGGYML SRKQSRNDEA NQDLQSLLTS GSGAPAARTK AKTSGANKGR
     LGEQEAFAMT VPLLIDVDSS QQEALEAIAL NDELVRVRRA LYLDLGVPFP GIHLRFNEGM
     GEGEYLISLQ EVPVARGELK AGYLLVRESV SQLELLGIPY EKGEHLLPDQ ETFWVSVEYE
     ERLEKSQLEF FSHSQVLTWH LSHVLREYAE DFIGIQETRY LLEQMEGGYG ELIKEVQRIV
     PLQRMTEILQ RLVGEDISIR NMRSILEAMV EWGQKEKDVV QLTEYIRSSL KRYICYKYAN
     GNNILPAYLF DQEVEEKIRS GVRQTSAGSY LALDPAVTES LLEQVRKTIG DLSQIQSKPV
     LIVSMDIRRY VRKLIESEYY GLPVLSYQEL TQQINIQPLG RVCL