LCRD_YERPE
ID LCRD_YERPE Reviewed; 704 AA.
AC P69955; P31487; Q56976; Q663K6;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Low calcium response locus protein D;
GN Name=lcrD; OrderedLocusNames=YPCD1.34c, y5044, y0047, YP_pCD49;
OS Yersinia pestis.
OG Plasmid pCD1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1657887; DOI=10.1128/jb.173.22.7293-7303.1991;
RA Plano G.V., Barve S.S., Straley S.C.;
RT "LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium
RT response.";
RL J. Bacteriol. 173:7293-7303(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Could be involved in the secretion of the yop virulence
CC proteins.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000305}.
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DR EMBL; M77014; AAA27643.1; -; Genomic_DNA.
DR EMBL; AF074612; AAC69797.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62571.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54911.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58568.1; -; Genomic_DNA.
DR PIR; A41321; A41321.
DR RefSeq; NP_395168.1; NC_003131.1.
DR RefSeq; NP_857748.1; NC_004836.1.
DR RefSeq; NP_857943.1; NC_004839.1.
DR RefSeq; WP_002212971.1; NZ_WUCM01000070.1.
DR AlphaFoldDB; P69955; -.
DR SMR; P69955; -.
DR IntAct; P69955; 4.
DR MINT; P69955; -.
DR STRING; 214092.5832454; -.
DR EnsemblBacteria; AAS58568; AAS58568; YP_pCD49.
DR GeneID; 66841114; -.
DR KEGG; ype:YPCD1.34c; -.
DR KEGG; ypm:YP_pCD49; -.
DR PATRIC; fig|214092.21.peg.45; -.
DR eggNOG; COG4789; Bacteria.
DR HOGENOM; CLU_015346_3_0_6; -.
DR OMA; PQFIGLQ; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 1.10.8.540; -; 1.
DR Gene3D; 3.40.30.60; -; 1.
DR Gene3D; 3.40.50.12790; -; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR InterPro; IPR006302; T3SS_HrcV.
DR PANTHER; PTHR30161; PTHR30161; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR TIGRFAMs; TIGR01399; hrcV; 1.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Plasmid; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Virulence.
FT CHAIN 1..704
FT /note="Low calcium response locus protein D"
FT /id="PRO_0000190030"
FT TRANSMEM 18..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 388
FT /note="I -> N (in Ref. 1; AAA27643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 704 AA; 77802 MW; 21B25E2486910B56 CRC64;
MNPHDLEWLN RIGERKDIML AVLLLAVVFM MVLPLPPLVL DILIAVNMTI SVVLLMIAIY
INSPLQFSAF PAVLLVTTLF RLALSVSTTR MILLQADAGQ IVYTFGNFVV GGNLIVGIVI
FLIITIVQFL VITKGSERVA EVSARFSLDA MPGKQMSIDG DMRAGVIDVN EARERRATIE
KESQMFGSMD GAMKFVKGDA IAGLIIIFVN ILGGVTIGVT QKGLAAAEAL QLYSILTVGD
GMVSQVPALL IAITAGIIVT RVSSEDSSDL GSDIGKQVVA QPKAMLIGGV LLLLFGLIPG
FPTVTFLILA LLVGCGGYML SRKQSRNDEA NQDLQSILTS GSGAPAARTK AKTSGANKGR
LGEQEAFAMT VPLLIDVDSS QQEALEAIAL NDELVRVRRA LYLDLGVPFP GIHLRFNEGM
GEGEYIISLQ EVPVARGELK AGYLLVRESV SQLELLGIPY EKGEHLLPDQ EAFWVSVEYE
ERLEKSQLEF FSHSQVLTWH LSHVLREYAE DFIGIQETRY LLEQMEGGYG ELIKEVQRIV
PLQRMTEILQ RLVGEDISIR NMRSILEAMV EWGQKEKDVV QLTEYIRSSL KRYICYKYAN
GNNILPAYLF DQEVEEKIRS GVRQTSAGSY LALEPAVTES LLEQVRKTIG DLSQIQSKPV
LIVSMDIRRY VRKLIESEYY GLPVLSYQEL TQQINIQPLG RICL
