ID   LCRH_YERPE              Reviewed;         168 AA.
AC   P21207;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=Low calcium response locus protein H;
GN   Name=lcrH; Synonyms=sycD;
GN   OrderedLocusNames=YPCD1.30c, y5048, y0051, YP_pCD53;
OS   Yersinia pestis.
OG   Plasmid pCD1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=2477361; DOI=10.1128/jb.171.10.5646-5653.1989;
RA   Price S.B., Leung K.Y., Barve S.S., Straley S.C.;
RT   "Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis.";
RL   J. Bacteriol. 171:5646-5653(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA   Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA   Blattner F.R.;
RT   "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT   Yersinia pestis KIM5.";
RL   Infect. Immun. 66:4611-4623(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Mediates the negative regulation of the lcrGVH operon by ATP
CC       or calcium. Acts as a modulator of the yop operon expression.
CC   -!- SIMILARITY: Belongs to the LcrH/SycD chaperone family. {ECO:0000305}.
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DR   EMBL; M26405; AAA27642.1; -; Genomic_DNA.
DR   EMBL; AF074612; AAC69800.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62575.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54907.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58572.1; -; Genomic_DNA.
DR   PIR; C33601; C33601.
DR   RefSeq; NP_395164.1; NC_003131.1.
DR   RefSeq; NP_857752.1; NC_004836.1.
DR   RefSeq; NP_857947.1; NC_004839.1.
DR   RefSeq; WP_002222758.1; NZ_WUCM01000070.1.
DR   AlphaFoldDB; P21207; -.
DR   SMR; P21207; -.
DR   STRING; 214092.5832450; -.
DR   DNASU; 1149311; -.
DR   EnsemblBacteria; AAS58572; AAS58572; YP_pCD53.
DR   KEGG; ype:YPCD1.30c; -.
DR   KEGG; ypm:YP_pCD53; -.
DR   PATRIC; fig|214092.21.peg.41; -.
DR   eggNOG; COG0457; Bacteria.
DR   HOGENOM; CLU_093829_2_1_6; -.
DR   OMA; NEPRFPF; -.
DR   Proteomes; UP000000815; Plasmid pCD1.
DR   Proteomes; UP000001019; Plasmid pCD1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005415; T3SS_Ca_resp_chp_LcrH/SycD.
DR   InterPro; IPR016379; T3SS_Ca_resp_chp_LcrH/SycD_sub.
DR   InterPro; IPR011716; TPR-3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF07720; TPR_3; 1.
DR   PIRSF; PIRSF003165; Chaperone_SicA; 1.
DR   PRINTS; PR01595; SYCDCHAPRONE.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   TIGRFAMs; TIGR02552; LcrH_SycD; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Chaperone; Plasmid; Reference proteome.
FT   CHAIN           1..168
FT                   /note="Low calcium response locus protein H"
FT                   /id="PRO_0000206485"
SQ   SEQUENCE   168 AA;  19015 MW;  46206AF240EB0064 CRC64;
     MQQETTDTQE YQLAMESFLK GGGTIAMLNE ISSDTLEQLY SLAFNQYQSG KYEDAHKVFQ
     ALCVLDHYDS RFFLGLGACR QAMGQYDLAI HSYSYGAIMD IKEPRFPFHA AECLLQKGEL
     AEAESGLFLA QELIADKTEF KELSTRVSSM LEAIKLKKEM EHECVDNP