ID   LCRR_YERPE              Reviewed;         146 AA.
AC   P69959; P19393; P31488; Q663K7;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Low calcium response locus protein R;
GN   Name=lcrR; OrderedLocusNames=YPCD1.33c, y5045, y0048, YP_pCD50;
OS   Yersinia pestis.
OG   Plasmid pCD1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=1695896; DOI=10.1128/jb.172.8.4661-4671.1990;
RA   Barve S.S., Straley S.C.;
RT   "lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in
RT   Yersinia pestis.";
RL   J. Bacteriol. 172:4661-4671(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA   Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA   Blattner F.R.;
RT   "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT   Yersinia pestis KIM5.";
RL   Infect. Immun. 66:4611-4623(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM5 / Biovar Mediaevalis;
RX   PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA   Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA   Brubaker R.R., Garcia E.;
RT   "Structural organization of virulence-associated plasmids of Yersinia
RT   pestis.";
RL   J. Bacteriol. 180:5192-5202(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Involved in the down-regulation of lcrGVH transcription in
CC       the presence or absence of calcium and is necessary for lcrG protein
CC       expression in the absence of calcium. Plays an important role in the
CC       regulation of the low-calcium response.
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DR   EMBL; M35740; AAA98219.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AF074612; AAC69831.1; -; Genomic_DNA.
DR   EMBL; AF053946; AAC62572.1; -; Genomic_DNA.
DR   EMBL; AL117189; CAB54910.1; -; Genomic_DNA.
DR   EMBL; AE017043; AAS58569.1; -; Genomic_DNA.
DR   PIR; A37774; A37774.
DR   PIR; T43592; T43592.
DR   RefSeq; NP_395167.1; NC_003131.1.
DR   RefSeq; NP_857749.1; NC_004836.1.
DR   RefSeq; NP_857944.1; NC_004839.1.
DR   RefSeq; WP_002220918.1; NZ_WUCM01000070.1.
DR   AlphaFoldDB; P69959; -.
DR   IntAct; P69959; 2.
DR   STRING; 214092.5832453; -.
DR   DNASU; 1149308; -.
DR   EnsemblBacteria; AAS58569; AAS58569; YP_pCD50.
DR   GeneID; 66841115; -.
DR   KEGG; ype:YPCD1.33c; -.
DR   KEGG; ypm:YP_pCD50; -.
DR   PATRIC; fig|214092.21.peg.44; -.
DR   eggNOG; ENOG5032XT5; Bacteria.
DR   HOGENOM; CLU_1864306_0_0_6; -.
DR   OMA; IEVTPYF; -.
DR   Proteomes; UP000000815; Plasmid pCD1.
DR   Proteomes; UP000001019; Plasmid pCD1.
DR   InterPro; IPR022797; LcrR/CesD2.
DR   InterPro; IPR013405; T3SS_LcrR.
DR   Pfam; PF09621; LcrR; 1.
DR   TIGRFAMs; TIGR02572; LcrR; 1.
PE   4: Predicted;
KW   Calcium; Plasmid; Reference proteome.
FT   CHAIN           1..146
FT                   /note="Low calcium response locus protein R"
FT                   /id="PRO_0000084374"
FT   CONFLICT        5
FT                   /note="P -> L (in Ref. 1; AAA98219)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        120
FT                   /note="S -> C (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   146 AA;  16454 MW;  611A80CB2A2FF2F9 CRC64;
     MMADPLIPWL TEHGLVCHPH TLSGTPISLG SAFQLAGLKL AWRVEIEQRR VWIVLIQRVE
     QRRGLKNPFA ALYMLANAAR AVLGPDYYLY GNVDVLAGSS LSTQRLAHFY RRWTGAKELS
     TGWFSLKVSQ VITLSNMKKR QNNGFA