ID   LCRV_YERPG              Reviewed;         326 AA.
AC   A9R9H4; O68697; P0C556; P21206; Q9L9Q7; Q9L9Q8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Virulence-associated V antigen;
DE   AltName: Full=Low calcium response locus protein V;
GN   Name=lcrV; Synonyms=icrV; OrderedLocusNames=YpAngola_B0032;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OG   Plasmid new_pCD.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10747136; DOI=10.1128/jcm.38.4.1516-1519.2000;
RA   Adair D.M., Worsham P.L., Hill K.K., Klevytska A.M., Jackson P.J.,
RA   Friedlander A.M., Keim P.;
RT   "Diversity in a variable-number tandem repeat from Yersinia pestis.";
RL   J. Clin. Microbiol. 38:1516-1519(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Possibly involved in calcium regulation of YOP expression,
CC       which includes the export process. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF167310; AAF64077.1; -; Genomic_DNA.
DR   EMBL; CP000902; ABX88711.1; -; Genomic_DNA.
DR   RefSeq; WP_012228705.1; NZ_CP009937.1.
DR   AlphaFoldDB; A9R9H4; -.
DR   SMR; A9R9H4; -.
DR   KEGG; ypg:YpAngola_B0032; -.
DR   PATRIC; fig|349746.12.peg.4433; -.
DR   OMA; EKMSQTT; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005413; LowCa_resp_V_Ag.
DR   InterPro; IPR036139; Vir_assoc_V_ag_sf.
DR   Pfam; PF04792; LcrV; 1.
DR   PRINTS; PR01592; LCRVANTIGEN.
DR   SUPFAM; SSF103388; SSF103388; 1.
PE   3: Inferred from homology;
KW   Plasmid; Secreted; Virulence.
FT   CHAIN           1..326
FT                   /note="Virulence-associated V antigen"
FT                   /id="PRO_0000343845"
SQ   SEQUENCE   326 AA;  37238 MW;  8752D1AFB2644C38 CRC64;
     MIRAYEQNPQ HFIEDLENVR VEQLTGHGSS VLEELVQLVK DKNIDISIKY DPRKDSEVFA
     NRVITDDIEL LRKILAYFLP EDAILKGGHY DNQLQNGIKR VKEFLESSPN TQWELRAFMA
     VMHFSLTADR IDDDILKVIV DSMNHHGDAR SKLREELAEL TAELKIYSVI QAEINKHLSS
     SGTINIHDKS INLMDKNLYG YTDEEIFKAS AEYKILEKMP QTTIQVDGSE KKIVSIKDFL
     GSENKRTGAL GNLKNSYSYN KDNNELSHFA TTSSDKSRPL NDLVSQKTTQ LSDITSRFNS
     AIEALNRFIQ KYDSVMQRLL DDTSGK