ID   LCRV_YERPS              Reviewed;         326 AA.
AC   P23994; Q663K9;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Virulence-associated V antigen;
DE   AltName: Full=Low calcium response locus protein V;
GN   Name=lcrV; OrderedLocusNames=pYV0057;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OG   Plasmid pIB1, and Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=YPIII / Serotype O:3; PLASMID=pIB1;
RX   PubMed=1705541; DOI=10.1128/jb.173.5.1607-1616.1991;
RA   Bergman T., Haakansson S., Forsberg A., Norlander L., Macellaro A.,
RA   Baeckman A., Boelin I., Wolf-Watz H.;
RT   "Analysis of the V antigen lcrGVH-yopBD operon of Yersinia
RT   pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV.";
RL   J. Bacteriol. 173:1607-1616(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serotype IA; PLASMID=pYV;
RX   PubMed=9009295; DOI=10.1128/iai.65.2.446-451.1997;
RA   Roggenkamp A., Geiger A.M., Leitritz L., Kessler A., Heesemann J.;
RT   "Passive immunity to infection with Yersinia spp. mediated by anti-
RT   recombinant V antigen is dependent on polymorphism of V antigen.";
RL   Infect. Immun. 65:446-451(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953; PLASMID=pYV;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Involved in calcium regulation of yop expression, which
CC       includes the export process.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; M57893; AAA27645.1; -; Genomic_DNA.
DR   EMBL; X96802; CAA65594.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25400.1; -; Genomic_DNA.
DR   PIR; B37314; B37314.
DR   RefSeq; WP_011191383.1; NZ_CP009711.1.
DR   AlphaFoldDB; P23994; -.
DR   SMR; P23994; -.
DR   EnsemblBacteria; CAF25400; CAF25400; pYV0057.
DR   GeneID; 66841117; -.
DR   KEGG; ypo:BZ17_4276; -.
DR   KEGG; yps:pYV0057; -.
DR   PATRIC; fig|273123.14.peg.4512; -.
DR   OMA; EKMSQTT; -.
DR   Proteomes; UP000001011; Plasmid pYV.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005413; LowCa_resp_V_Ag.
DR   InterPro; IPR036139; Vir_assoc_V_ag_sf.
DR   Pfam; PF04792; LcrV; 1.
DR   PRINTS; PR01592; LCRVANTIGEN.
DR   SUPFAM; SSF103388; SSF103388; 1.
PE   4: Predicted;
KW   Plasmid; Secreted; Virulence.
FT   CHAIN           1..326
FT                   /note="Virulence-associated V antigen"
FT                   /id="PRO_0000084381"
SQ   SEQUENCE   326 AA;  37336 MW;  2FD9455DAFF48C06 CRC64;
     MIRAYEQNPQ HFIEDLEKVR VEQLTGHGSS VLEELVQLVK DKNIDISIKY DPRKDSEVFA
     NRVITDDIEL LKKILAYFLP EDAILKGGHY DNQLQNGIKR VKEFLESSPN TQWELRAFMA
     VIHFSLTADR IDDDILKVIV DSMNHHGDAR SKLREELAEL TAELKIYSVI QAEINKHLSS
     GGTINIHDKS INLMDKNLYG YTDEEIFKAS AEYKILEKMP QTTIQEGETE KKIVSIKNFL
     ESEKKRTGAL GNLKDSYSYN KDNNELSHFA TTCSDKSRPL NDLVSQKTTQ LSDITSRFNS
     AIEALNRFIQ KYDSVMQRLL DDTSGK