ID   LCSL_PURLI              Reviewed;         419 AA.
AC   A0A179G9G5;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Transcription regulator lscL {ECO:0000303|PubMed:27416025};
DE   AltName: Full=Leucinostatins biosynthesis cluster protein L {ECO:0000303|PubMed:27416025};
GN   Name=lcsL {ECO:0000303|PubMed:27416025}; ORFNames=VFPBJ_11786;
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=PLBJ-1;
RX   PubMed=27416025; DOI=10.1371/journal.ppat.1005685;
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT   Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT   genome mining.";
RL   PLoS Pathog. 12:E1005685-E1005685(2016).
CC   -!- FUNCTION: Transcription factor that may coregulate the expression of
CC       the gene cluster that mediates the biosynthesis of the lipopeptide
CC       antibiotics leucinostatins that show extensive biological activities,
CC       including antimalarial, antiviral, antibacterial, antifungal, and
CC       antitumor activities, as well as phytotoxic.
CC       {ECO:0000269|PubMed:27416025}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is negatively regulated by the leucinostatins
CC       biosynthesis cluster-specific transcription regulator lcsF.
CC       {ECO:0000269|PubMed:27416025}.
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DR   EMBL; LSBH01000009; OAQ74455.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A179G9G5; -.
DR   SMR; A0A179G9G5; -.
DR   EnsemblFungi; OAQ74455; OAQ74455; VFPBJ_11786.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..419
FT                   /note="Transcription regulator lscL"
FT                   /id="PRO_0000446609"
FT   DNA_BIND        12..35
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   419 AA;  45778 MW;  1E0ED74CE1AF109E CRC64;
     MHLDWTLVLA SRIRKVKCDE KKPCCQKCID TGRTCDGYES PFRVVTSRSI INGARASGIP
     GAASRPVRPA LTEISPADID LLNRYFSTKT MFDVKLGCDE EAREVLEASL TDPTVRHAVS
     SLRSLREHLE TSGDVSASAA QQSPSYGYDY GVQQYCMALG GLASNLSSPG SNALKSALLC
     CQIFISIEQV RGNYGTMAQH IIQGLGIMHE YRARPTLDDA NNLVPAHHAQ LPLLDAFVIK
     LFAAPCKFAE PSATADKEGG KAVSMCAISR HEQTVGSRNL RTIVPDMRTE LTRISTSTLD
     FLVKVSSVDS AGNALRLLPE KTALLESLKS WLMDLELVHA DIKSPGTEPL AVSFLRLFHQ
     ILKIILVEAL NSSSNLQAEL RTENDRLQGI GSIIDERVQS QRKNSSALDL IDNRLKCPA