ID   LCSM_PURLI              Reviewed;          82 AA.
AC   A0A179HM40;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Leucinostatins biosynthesis cluster protein M {ECO:0000303|PubMed:27416025};
GN   Name=lcsM {ECO:0000303|PubMed:27416025}; ORFNames=VFPBJ_02526, VFPFJ_04698;
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=PLBJ-1;
RX   PubMed=27416025; DOI=10.1371/journal.ppat.1005685;
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT   Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT   genome mining.";
RL   PLoS Pathog. 12:E1005685-E1005685(2016).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       the lipopeptide antibiotics leucinostatins that show extensive
CC       biological activities, including antimalarial, antiviral,
CC       antibacterial, antifungal, and antitumor activities, as well as
CC       phytotoxic (PubMed:27416025). The function of lcsM within the
CC       leucinostatins biosynthesis has not been identified yet (Probable).
CC       {ECO:0000269|PubMed:27416025, ECO:0000305|PubMed:27416025}.
CC   -!- INDUCTION: Expression is positively regulated by the leucinostatins
CC       biosynthesis cluster-specific transcription regulator lcsF.
CC       {ECO:0000269|PubMed:27416025}.
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DR   EMBL; LSBH01000002; OAQ83759.1; -; Genomic_DNA.
DR   EMBL; LSBI01000004; OAQ90539.1; -; Genomic_DNA.
DR   RefSeq; XP_018179258.1; XM_018321778.1.
DR   AlphaFoldDB; A0A179HM40; -.
DR   EnsemblFungi; OAQ83759; OAQ83759; VFPBJ_02526.
DR   EnsemblFungi; OAQ90539; OAQ90539; VFPFJ_04698.
DR   GeneID; 28886827; -.
DR   KEGG; plj:VFPFJ_04698; -.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..82
FT                   /note="Leucinostatins biosynthesis cluster protein M"
FT                   /id="PRO_0000446616"
FT   REGION          34..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   82 AA;  9090 MW;  C19671134B0EB3E8 CRC64;
     MCRCRHPSCI TETVFPPLTW LDSEWDEICS LPVARNETHD PSGPRAPVSS MRLGPRSRPY
     HHGTARLRGS PNCSRDSSSA AT