ID   LCSO_PURLI              Reviewed;         593 AA.
AC   A0A179HKZ8;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=ABC1 family protein lscO {ECO:0000303|PubMed:27416025};
DE   AltName: Full=Leucinostatins biosynthesis cluster protein O {ECO:0000303|PubMed:27416025};
GN   Name=lcsO {ECO:0000303|PubMed:27416025}; ORFNames=VFPBJ_02529, VFPFJ_04701;
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=PLBJ-1;
RX   PubMed=27416025; DOI=10.1371/journal.ppat.1005685;
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT   Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT   genome mining.";
RL   PLoS Pathog. 12:E1005685-E1005685(2016).
CC   -!- FUNCTION: ABC1 family protein; part of the gene cluster that mediates
CC       the biosynthesis of the lipopeptide antibiotics leucinostatins that
CC       show extensive biological activities, including antimalarial,
CC       antiviral, antibacterial, antifungal, and antitumor activities, as well
CC       as phytotoxic (PubMed:27416025). The function of lcsO within the
CC       leucinostatins biosynthesis has not been identified yet (Probable).
CC       {ECO:0000269|PubMed:27416025, ECO:0000305|PubMed:27416025}.
CC   -!- INDUCTION: Expression is positively regulated by the leucinostatins
CC       biosynthesis cluster-specific transcription regulator lcsF.
CC       {ECO:0000269|PubMed:27416025}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; LSBH01000002; OAQ83762.1; -; Genomic_DNA.
DR   EMBL; LSBI01000004; OAQ90542.1; -; Genomic_DNA.
DR   RefSeq; XP_018179261.1; XM_018321781.1.
DR   AlphaFoldDB; A0A179HKZ8; -.
DR   SMR; A0A179HKZ8; -.
DR   STRING; 33203.A0A179HKZ8; -.
DR   EnsemblFungi; OAQ83762; OAQ83762; VFPBJ_02529.
DR   EnsemblFungi; OAQ90542; OAQ90542; VFPFJ_04701.
DR   GeneID; 28886830; -.
DR   KEGG; plj:VFPFJ_04701; -.
DR   OrthoDB; 790106at2759; -.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
DR   CDD; cd13969; ADCK1-like; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR045307; ADCK1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..593
FT                   /note="ABC1 family protein lscO"
FT                   /id="PRO_0000446610"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..467
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  67402 MW;  CDB9A9F5858E68F4 CRC64;
     MDVAFPGMER HDEKNPPGDD GTKPTGGKKA RPAIKIKWYW KGLILLVELC IGDYLLDRYV
     FGGVMLRTTI AYAVLARVGL DYKLHYGKDC WLARHPEEDL HHRNAQRVCT MLKWNGGLYL
     KAGQAVAMQG SVLPEEYQRM FGEMFDDAPH SSWSDVEKVI KQDFGGRSIE DVFGVAPSDQ
     QGDSQFVFER EPRASASIAQ VHYARLPDGR GLAVKVQRRE ISKQVSWDLW SMKLMTEYTA
     WVTGLPMGGM GQFVADRVMQ ETDFEHEASN SEKMADLIAT DSSLRDRVYI PKVYREFTSK
     RVLTTEWVDA VQLWDRDAIT GQVAPSRSAT SDKPGLGLRL DDVMRTVVEL FSAQMFSWGF
     VHCDPHPGNI LVRQNPKRPD SAQVVLLDHG LYITMSDKLR RQYARFWKAL VTNDDASLQR
     VSREWGMKSA DAWADASLMR PYKNPSSSDD ESGESWQRTK ETPEERKQRM IDEAAAYLGD
     EGLFPRELLF LERNITIVQG NNRFLGSPVN RIKLIGSCAL KAIRDDGQGK ESIRERISTR
     VALLSLDLAF WWSAMKQYFG YGEGLEQELK EAEDRQLRET KDAVAELFGI TVN