ID   LCSS_PURLI              Reviewed;         243 AA.
AC   A0A179HM59;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Leucinostatins biosynthesis cluster protein S {ECO:0000303|PubMed:27416025};
GN   Name=lcsS {ECO:0000303|PubMed:27416025};
GN   ORFNames=PCL_01813, VFPBJ_02536, VFPFJ_04709;
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=36-1;
RX   PubMed=27486440; DOI=10.3389/fmicb.2016.01084;
RA   Xie J., Li S., Mo C., Xiao X., Peng D., Wang G., Xiao Y.;
RT   "Genome and transcriptome sequences reveal the specific parasitism of the
RT   nematophagous Purpureocillium lilacinum 36-1.";
RL   Front. Microbiol. 7:1084-1084(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=PLBJ-1;
RX   PubMed=27416025; DOI=10.1371/journal.ppat.1005685;
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT   Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT   genome mining.";
RL   PLoS Pathog. 12:E1005685-E1005685(2016).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       the lipopeptide antibiotics leucinostatins that show extensive
CC       biological activities, including antimalarial, antiviral,
CC       antibacterial, antifungal, and antitumor activities, as well as
CC       phytotoxic (PubMed:27416025). The function of lcsS within the
CC       leucinostatins biosynthesis has not been identified yet (Probable).
CC       {ECO:0000269|PubMed:27416025, ECO:0000305|PubMed:27416025}.
CC   -!- INDUCTION: Expression is positively regulated by the leucinostatins
CC       biosynthesis cluster-specific transcription regulator lcsF.
CC       {ECO:0000269|PubMed:27416025}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LSBH01000002; OAQ83770.1; -; Genomic_DNA.
DR   EMBL; LSBI01000004; OAQ90550.1; -; Genomic_DNA.
DR   EMBL; LCWV01000014; PWI68724.1; -; Genomic_DNA.
DR   RefSeq; XP_018179269.1; XM_018321789.1.
DR   AlphaFoldDB; A0A179HM59; -.
DR   SMR; A0A179HM59; -.
DR   EnsemblFungi; OAQ83770; OAQ83770; VFPBJ_02536.
DR   EnsemblFungi; OAQ90550; OAQ90550; VFPFJ_04709.
DR   GeneID; 28886838; -.
DR   KEGG; plj:VFPFJ_04709; -.
DR   OrthoDB; 1269738at2759; -.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
DR   Proteomes; UP000245956; Unassembled WGS sequence.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..243
FT                   /note="Leucinostatins biosynthesis cluster protein S"
FT                   /id="PRO_0000446617"
SQ   SEQUENCE   243 AA;  27141 MW;  25BAAAEECAE0EF83 CRC64;
     MTLYFAYPNA ESGDCKCLGL IFFVKDYYGE KVFPPIGCVG ITQFENQASK TNYFSNVDKA
     RSLQKRFMEE AGVDVVGRVK ALLQSIVPPG LPVRLAQEDG KSYFAGLLRL INSSALIHAD
     YGPFDGPGWE IGAIKAQLTW NILLKEVRGG ESVVYNRFWK GKEDDDKYRD VTKSYGYSRD
     VIDGCESKKI APIVGQIALF NPRNFHEVLA IENPEKVSRY TFSSFIGYLP PTAPEGPAII
     LWS