ID   LCST_PURLI              Reviewed;         269 AA.
AC   A0A179H2Q3;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Leucinostatins biosynthesis cluster protein T {ECO:0000303|PubMed:27416025};
DE   Flags: Precursor;
GN   Name=lcsT {ECO:0000303|PubMed:27416025}; ORFNames=VFPBJ_02538, VFPFJ_04710;
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP   AND INDUCTION.
RC   STRAIN=PLBJ-1;
RX   PubMed=27416025; DOI=10.1371/journal.ppat.1005685;
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT   Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT   genome mining.";
RL   PLoS Pathog. 12:E1005685-E1005685(2016).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       the lipopeptide antibiotics leucinostatins that show extensive
CC       biological activities, including antimalarial, antiviral,
CC       antibacterial, antifungal, and antitumor activities, as well as
CC       phytotoxic (PubMed:27416025). The function of lcsT within the
CC       leucinostatins biosynthesis has not been identified yet (Probable).
CC       {ECO:0000269|PubMed:27416025, ECO:0000305|PubMed:27416025}.
CC   -!- INDUCTION: Expression is positively regulated by the leucinostatins
CC       biosynthesis cluster-specific transcription regulator lcsF.
CC       {ECO:0000269|PubMed:27416025}.
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DR   EMBL; LSBH01000002; OAQ83771.1; -; Genomic_DNA.
DR   EMBL; LSBI01000004; OAQ90551.1; -; Genomic_DNA.
DR   RefSeq; XP_018179270.1; XM_018321790.1.
DR   AlphaFoldDB; A0A179H2Q3; -.
DR   EnsemblFungi; OAQ83771; OAQ83771; VFPBJ_02538.
DR   EnsemblFungi; OAQ90551; OAQ90551; VFPFJ_04710.
DR   GeneID; 28886839; -.
DR   KEGG; plj:VFPFJ_04710; -.
DR   OrthoDB; 1490073at2759; -.
DR   Proteomes; UP000078240; Unassembled WGS sequence.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..269
FT                   /note="Leucinostatins biosynthesis cluster protein T"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5011877981"
FT   CARBOHYD        254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   269 AA;  29591 MW;  027445F352F06CBC CRC64;
     MHIILTGTGL VGAIALDAML QESSIDKITI ISRKPVPQAE GQSKVEVIIQ EDLSTYSDET
     LAKLKGAHGC IWTAGPPLMA VTRQEYEYGH IDLPVKAAKA FAALNDKFNF VYVSHDGCHD
     TRAVYIFDVK ARAEEKLFQL HHDPSKRLEI KTKGGIEEQE SLSSFVLYCI RPALIDYSTH
     DAIKPWLKPL PLAKKWTNGV ILPLYRFLGL TSIMGTSQEL GQAMKDLVIS DGRDVDVAGA
     SPEGRCLGAV GMRNWTQARN ESPEDTVAV