ID   LCTP_ALKHC              Reviewed;         524 AA.
AC   Q9K5Z9;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=L-lactate permease;
GN   Name=lctP; OrderedLocusNames=BH3936;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: May play a role in L-lactate transport.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the lactate permease family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB07655.1; -; Genomic_DNA.
DR   PIR; H84141; H84141.
DR   RefSeq; WP_010900061.1; NC_002570.2.
DR   AlphaFoldDB; Q9K5Z9; -.
DR   STRING; 272558.10176561; -.
DR   EnsemblBacteria; BAB07655; BAB07655; BAB07655.
DR   KEGG; bha:BH3936; -.
DR   eggNOG; COG1620; Bacteria.
DR   HOGENOM; CLU_021628_0_0_9; -.
DR   OMA; VIVLWIQ; -.
DR   OrthoDB; 732251at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
DR   TIGRFAMs; TIGR00795; lctP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..524
FT                   /note="L-lactate permease"
FT                   /id="PRO_0000210372"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   524 AA;  55629 MW;  0376ED4D9A31AFF6 CRC64;
     MLVETYDPFQ HLAVSAFVAA IPILLLLLCL TVFKMQGIQA ALLTLLVTFF IAGLVFHLPF
     GESIGSIVQG VVQGLWPIGY IIVMAVWLYK IAVASGKFAV LRGSIIGISR DQRIQLLLIG
     FCFNAFLEGA AGFGVPIAIC AVLLVSLGFK PLQAAMLCLI ANGASGAFGA IGIPVGIIDT
     LGLEGQVTSM DVSMMTALTL PMINFTIPFL LIWLMDSWKG IKEILPAILV TSSVYTVSQA
     LITIFIGPEL ADIIPSLLTM GLLALFLKRW QPRNTFLLNG NGCESEHASL KDVIKAWSPF
     YLLTMFVFLW SLPAFKGLLA EGGALEFAKW AFVVPGSSIE VGVDFIGATG TAILLAAVTT
     VTTTKMIRMK ESISLLKKVI VDFSIPIMMI CAIIGIAKLM TYGGLTMALG EAVATTGAFF
     PFLSPILGWI GVFMTGSVVN NNTLFAPIQT TAGAIIGTNP SLLVAANTAG GVMAKLVSPQ
     SIAIATAAVG ETGNEAALTK MTLKYSFGLL VFVSVWTYIL SLLF