ID   LCTP_STRIN              Reviewed;         474 AA.
AC   O33654;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=L-lactate permease;
GN   Name=lctP;
OS   Streptococcus iniae (Streptococcus shiloi).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1346;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10508058; DOI=10.1128/aem.65.10.4346-4350.1999;
RA   Gibello A., Collins M.D., Dominguez L., Fernandez-Garayzabal J.F.,
RA   Richardson P.T.;
RT   "Cloning and analysis of the L-lactate utilization genes from Streptococcus
RT   iniae.";
RL   Appl. Environ. Microbiol. 65:4346-4350(1999).
CC   -!- FUNCTION: Plays a role in L-lactate utilization.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the lactate permease family. {ECO:0000305}.
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DR   EMBL; Y07622; CAA68902.1; -; Genomic_DNA.
DR   AlphaFoldDB; O33654; -.
DR   STRING; 1346.DQ08_07075; -.
DR   eggNOG; COG1620; Bacteria.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; PTHR30003; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
DR   TIGRFAMs; TIGR00795; lctP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..474
FT                   /note="L-lactate permease"
FT                   /id="PRO_0000210379"
FT   TRANSMEM        4..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   474 AA;  50808 MW;  8EA1BC09754284E2 CRC64;
     MFQAILAIIP ILWLILSLAV FRMRGDLACF IGLIITLLTS IIGFHFSIKD GLTAGLEGAM
     MGFWPIIYII VAAVFTYNLT TASGGMTVIK RLLMTITEDK RILVLILAWG FGGFLEAIAG
     FGTAVAIPAS ILVALGMKPL RAALICLIAN TTPTAFGAIG LPVTTLAQVT GLEVKQLSVI
     VSLQLFILIV AIPFVLVSLT GEGKRPIKGV FGITLASGLA FALPQILVSN YVGAELPSII
     GSLFCILVTI LFVNLRERGK NASPVGGDVA FKEGIIRCLP FILVFFFIML TSSLFPAINQ
     LLAKVSTTVS IYTGEHAKPY TIKWLTSPGT MIILATFIAG LIQGMSFKEI GSILAKVLNK
     LTKTMVTVAS IVALSKVMSY SGMINTIAVS LVAVTGGFYP FIAPVIGTLG TFITGSDTSA
     NVLFGELQVK AANNLNMNPY WMAAQYDRGN CRKNDFASKH CSCSGTYWFR RSRR