LCV2_ARATH
ID LCV2_ARATH Reviewed; 261 AA.
AC Q9C8C1; Q8LCZ6;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Protein LIKE COV 2 {ECO:0000303|PubMed:12668628};
GN Name=LCV2 {ECO:0000303|PubMed:12668628};
GN OrderedLocusNames=At1g43130 {ECO:0000312|Araport:AT1G43130};
GN ORFNames=F2H10.2 {ECO:0000312|EMBL:AAG50825.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=12668628; DOI=10.1242/dev.00441;
RA Parker G., Schofield R., Sundberg B., Turner S.;
RT "Isolation of COV1, a gene involved in the regulation of vascular
RT patterning in the stem of Arabidopsis.";
RL Development 130:2139-2148(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the plant COV1 protein family. {ECO:0000305}.
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DR EMBL; AC026757; AAG50825.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31947.1; -; Genomic_DNA.
DR EMBL; AK176692; BAD44455.1; -; mRNA.
DR EMBL; AK176760; BAD44523.1; -; mRNA.
DR EMBL; BT033158; ACF75547.1; -; mRNA.
DR EMBL; AY086303; AAM64375.1; -; mRNA.
DR RefSeq; NP_564483.1; NM_103466.5.
DR AlphaFoldDB; Q9C8C1; -.
DR STRING; 3702.AT1G43130.1; -.
DR iPTMnet; Q9C8C1; -.
DR PaxDb; Q9C8C1; -.
DR PRIDE; Q9C8C1; -.
DR ProteomicsDB; 237057; -.
DR EnsemblPlants; AT1G43130.1; AT1G43130.1; AT1G43130.
DR GeneID; 840912; -.
DR Gramene; AT1G43130.1; AT1G43130.1; AT1G43130.
DR KEGG; ath:AT1G43130; -.
DR Araport; AT1G43130; -.
DR TAIR; locus:2018640; AT1G43130.
DR eggNOG; ENOG502QQ9F; Eukaryota.
DR HOGENOM; CLU_068050_0_0_1; -.
DR InParanoid; Q9C8C1; -.
DR OMA; QNDRIPL; -.
DR OrthoDB; 1053970at2759; -.
DR PhylomeDB; Q9C8C1; -.
DR PRO; PR:Q9C8C1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8C1; baseline and differential.
DR Genevisible; Q9C8C1; AT.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0010222; P:stem vascular tissue pattern formation; ISS:TAIR.
DR InterPro; IPR007462; COV1-like.
DR PANTHER; PTHR31876; PTHR31876; 1.
DR Pfam; PF04367; DUF502; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..261
FT /note="Protein LIKE COV 2"
FT /id="PRO_0000431900"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..91
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 92..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 23
FT /note="D -> E (in Ref. 5; AAM64375)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="T -> A (in Ref. 5; AAM64375)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 29216 MW; F50020425FA4D0A2 CRC64;
MAEGKEATTS SLSQGLTPHQ DPDDAPKSPP NSPNSSTRKA CYGVLQSWVS KKFMTGFVVL
FPVAVTFLIT WWFIQFVDGF FSPIYENLGV DIFGLGFITS VLFTFFVGIF ASSWLGSTVF
WLGEQFIRRM PFVKHIYSAS KQISTAISPD QNTTAFKEVA IIRHPRIGEY AFGFITSSVT
LQTDHGEEEL CSVYVPTNHL YIGDVFLVSS EEIIRPNLSI REGIEIIVSV GMTMPQVISH
VDRTTNRTPH QHSLRVPLNR L
