ID   LCYD2_ORYSJ             Reviewed;         479 AA.
AC   Q5JNT6; Q0JNH6;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative L-cysteine desulfhydrase 2;
DE            EC=4.4.1.28;
DE   AltName: Full=OsL-CDes2;
DE            Short=L-CDes2;
GN   OrderedLocusNames=Os01g0290600, LOC_Os01g18660;
GN   ORFNames=P0469E05.32, P0706B05.1;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Catalyzes the production of hydrogen sulfide (H2S) from
CC       cysteine. {ECO:0000250|UniProtKB:Q9M1R1}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) +
CC         pyruvate; Xref=Rhea:RHEA:24931, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919,
CC         ChEBI:CHEBI:35235; EC=4.4.1.28;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000305}.
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DR   EMBL; AP002480; BAD86870.1; -; Genomic_DNA.
DR   EMBL; AP002482; BAD86871.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF04702.2; -; Genomic_DNA.
DR   EMBL; AP014957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015625397.1; XM_015769911.1.
DR   AlphaFoldDB; Q5JNT6; -.
DR   SMR; Q5JNT6; -.
DR   STRING; 4530.OS01T0290600-00; -.
DR   PaxDb; Q5JNT6; -.
DR   GeneID; 4325157; -.
DR   KEGG; osa:4325157; -.
DR   eggNOG; KOG1549; Eukaryota.
DR   HOGENOM; CLU_003433_3_2_1; -.
DR   InParanoid; Q5JNT6; -.
DR   OrthoDB; 516638at2759; -.
DR   BRENDA; 2.5.1.47; 8948.
DR   PlantReactome; R-OSA-1119612; Cysteine degradation.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   GO; GO:0080146; F:L-cysteine desulfhydrase activity; IEA:RHEA.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00266; Aminotran_5; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..479
FT                   /note="Putative L-cysteine desulfhydrase 2"
FT                   /id="PRO_0000429506"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         270
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   479 AA;  51237 MW;  9940DAD919611FE5 CRC64;
     MASLQSGGDA AANGVDADVD GAASPPSAKR PRAGAGAAAI TDAEVRAEFA HHDRAVARLN
     NGTFGCCPAS VLAARARWQR LFLSQPDAFY FHHLQPGLAR SRAAVAAAVG AGDASEVSLV
     DNVTTAAAII MQHVAWSFAE GDFARGDVVL MFLYTYCSIK NSIHAYVARA GATVVEVPLP
     FPVSSPDAIV AEFRAALAVA RDGGRRRVRL AVIDHITAMP TVLIPVKELV AICREEGVDK
     VFVDAAHAVG QVPVDVRDIG ADFYASNLHK WFFCPSAVAF IHTRKDDPVS SKLHHPVVSS
     EYGNGLPMES AWIGVRDYSA QLVVPDVVDF VNRFDGGVEG IRRRNHDKVV EMGTMLAAAW
     GTFLGTPPEM CGSMLMVGLP GSLGVGSEDD AVGLRTMLRK QFKVEVPLYY NSKAAAADAP
     PEMVKDGNGD PVTGYVRISH QVYNVREEYE ALRDAVAKLV ADGFTCRKLR PPEKEETLA