LDB2_CHICK
ID LDB2_CHICK Reviewed; 371 AA.
AC Q9W676; Q1EQW9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=LIM domain-binding protein 2;
DE Short=LDB-2;
DE AltName: Full=Carboxyl-terminal LIM domain-binding protein 1;
DE Short=CLIM-1;
DE AltName: Full=LIM domain-binding factor CLIM1;
DE Short=cLdb2;
GN Name=LDB2; Synonyms=CLIM1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD34207.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND TISSUE SPECIFICITY.
RC TISSUE=Limb {ECO:0000269|PubMed:10431247};
RX PubMed=10431247; DOI=10.1038/11970;
RA Bach I., Rodriguez-Esteban C., Carriere C., Bhushan A., Krones A.,
RA Rose D.W., Glass C.K., Andersen B., Izpisua-Belmonte J.-C., Rosenfeld M.G.;
RT "RLIM inhibits functional activity of LIM homeodomain transcription factors
RT via recruitment of the histone deacetylase complex.";
RL Nat. Genet. 22:394-399(1999).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAE95404.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), AND ALTERNATIVE SPLICING.
RC TISSUE=Fetus {ECO:0000269|PubMed:16815859};
RX PubMed=16815859; DOI=10.1093/jb/mvj134;
RA Tran Y.H., Xu Z., Kato A., Mistry A.C., Goya Y., Taira M., Brandt S.J.,
RA Hirose S.;
RT "Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the
RT LIM-interaction domain.";
RL J. Biochem. 140:105-119(2006).
CC -!- FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-
CC containing transcription factors. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000269|PubMed:10431247};
CC IsoId=Q9W676-1; Sequence=Displayed;
CC Name=b {ECO:0000269|PubMed:16815859};
CC IsoId=Q9W676-2; Sequence=VSP_052328, VSP_052329;
CC -!- TISSUE SPECIFICITY: First expressed at stages 15-16 in presumptive limb
CC mesoderm. As limb outgrowth proceeds, expressed in the entire limb bud,
CC concentrating in the distal mesoderm throughout limb development. Both
CC hindlimbs and forelimbs exhibit similar expression patterns.
CC {ECO:0000269|PubMed:10431247}.
CC -!- MISCELLANEOUS: [Isoform b]: Lacks LIM-binding domain.
CC {ECO:0000269|PubMed:16815859}.
CC -!- SIMILARITY: Belongs to the LDB family. {ECO:0000255}.
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DR EMBL; AF069990; AAD34207.1; -; mRNA.
DR EMBL; AB250386; BAE95404.1; -; mRNA.
DR RefSeq; NP_990160.1; NM_204829.1. [Q9W676-1]
DR AlphaFoldDB; Q9W676; -.
DR SMR; Q9W676; -.
DR STRING; 9031.ENSGALP00000036514; -.
DR PaxDb; Q9W676; -.
DR GeneID; 395631; -.
DR KEGG; gga:395631; -.
DR CTD; 9079; -.
DR VEuPathDB; HostDB:geneid_395631; -.
DR eggNOG; KOG2181; Eukaryota.
DR InParanoid; Q9W676; -.
DR OrthoDB; 849287at2759; -.
DR PhylomeDB; Q9W676; -.
DR PRO; PR:Q9W676; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0030274; F:LIM domain binding; ISS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR030174; LDB2.
DR InterPro; IPR041363; LID.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR PANTHER; PTHR10378:SF8; PTHR10378:SF8; 1.
DR Pfam; PF17916; LID; 1.
DR Pfam; PF01803; LIM_bind; 2.
DR PROSITE; PS51957; LID; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..371
FT /note="LIM domain-binding protein 2"
FT /id="PRO_0000284556"
FT DOMAIN 296..335
FT /note="LIM interaction domain (LID)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01302"
FT REGION 244..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 296..331
FT /note="DVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANG -> VPELGALQSCSL
FT NPGRDGALCHSTAVTPTGQFKEKH (in isoform b)"
FT /evidence="ECO:0000303|PubMed:16815859"
FT /id="VSP_052328"
FT VAR_SEQ 332..371
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:16815859"
FT /id="VSP_052329"
FT CONFLICT 175
FT /note="P -> A (in Ref. 2; BAE95404)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="L -> V (in Ref. 2; BAE95404)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="Missing (in Ref. 2; BAE95404)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 42607 MW; 6E6D9C97ADCF9BD9 CRC64;
MSSAPHDPFY SSPFGPFYRR HTPYMVQPEY RIYEMNKRLQ ARSEDSDNLW WDAFATEFFE
DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC
DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELVP RSILPMHAQD
PQVLEQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ
RMVAPPAEPT RQPTTKRRKR KNSTSSTSNS SAGNNANSTN SKKKSAAANL SLSSQDVMVV
GEPTLMGGEF GDEDERLITR LENTQYDAAN GMDDEEDFNN SPALGNNSPW NSKPPANQET
KSENPTPQAS Q
