ID   LDB2_XENLA              Reviewed;         398 AA.
AC   Q1EQW7; Q1EQW6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=LIM domain-binding protein 2;
DE            Short=LDB-2;
DE            Short=xLdb2;
GN   Name=ldb2 {ECO:0000312|EMBL:BAE95406.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAE95406.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), ALTERNATIVE SPLICING, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Brain {ECO:0000269|PubMed:16815859}, and
RC   Heart {ECO:0000269|PubMed:16815859};
RX   PubMed=16815859; DOI=10.1093/jb/mvj134;
RA   Tran Y.H., Xu Z., Kato A., Mistry A.C., Goya Y., Taira M., Brandt S.J.,
RA   Hirose S.;
RT   "Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the
RT   LIM-interaction domain.";
RL   J. Biochem. 140:105-119(2006).
CC   -!- FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-
CC       containing transcription factors. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000269|PubMed:16815859};
CC         IsoId=Q1EQW7-1; Sequence=Displayed;
CC       Name=a {ECO:0000269|PubMed:16815859};
CC         IsoId=Q1EQW7-2; Sequence=VSP_052327;
CC   -!- TISSUE SPECIFICITY: Expressed in adult brain, lung, spleen and kidney.
CC       Isoform b is generally expressed at a higher level than isoform a.
CC       {ECO:0000269|PubMed:16815859}.
CC   -!- DEVELOPMENTAL STAGE: Expressed weakly in the stage 10/10.5 embryo.
CC       Expression then resumes after stage 25. {ECO:0000269|PubMed:16815859}.
CC   -!- SIMILARITY: Belongs to the LDB family. {ECO:0000255}.
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DR   EMBL; AB250388; BAE95406.1; -; mRNA.
DR   EMBL; AB250389; BAE95407.1; -; mRNA.
DR   RefSeq; NP_001089184.1; NM_001095715.1. [Q1EQW7-1]
DR   AlphaFoldDB; Q1EQW7; -.
DR   SMR; Q1EQW7; -.
DR   GeneID; 734228; -.
DR   KEGG; xla:734228; -.
DR   CTD; 734228; -.
DR   Xenbase; XB-GENE-17336128; ldb2.L.
DR   OrthoDB; 849287at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734228; Expressed in brain and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030274; F:LIM domain binding; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR030174; LDB2.
DR   InterPro; IPR041363; LID.
DR   InterPro; IPR029005; LIM-bd/SEUSS.
DR   PANTHER; PTHR10378; PTHR10378; 2.
DR   PANTHER; PTHR10378:SF8; PTHR10378:SF8; 2.
DR   Pfam; PF17916; LID; 1.
DR   Pfam; PF01803; LIM_bind; 1.
DR   PROSITE; PS51957; LID; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Reference proteome.
FT   CHAIN           1..398
FT                   /note="LIM domain-binding protein 2"
FT                   /id="PRO_0000284557"
FT   DOMAIN          323..362
FT                   /note="LIM interaction domain (LID)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01302"
FT   REGION          245..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         298..322
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000303|PubMed:16815859"
FT                   /id="VSP_052327"
SQ   SEQUENCE   398 AA;  45908 MW;  E996225240B18B19 CRC64;
     MSSTPHDPFY SSPFGPFYRR HAPYMVQPEY RIYEMNKRLQ TRTEDSDNLW WDAFATEFFE
     DDATLTLSFC LEDGPKRYTI GRTLIPRYFS TVFEGGVTDL YYILKHSKES YHNSSITVDC
     DQCTMVTQHG KPMFTKVCTE GRLILEFTFD DLMRIKTWHF TIRQYRELLP RSILAMHAQD
     PQVLEQLSKN ITRMGLTNFT LNYLRLCVIL EPMQELMSRH KTYNLSPRDC LKTCLFQKWQ
     RMVAPPAEPT RQTTTKRRKR KNSTNNASNS NAGNNATSAY NRKKVPAASL NLSNQVPFPT
     TKKCIGDKTR VRRNYRGIRN GLDVMVVGEP TLMGGEFGDE DERLITRLEN TQYDAANGMD
     DEEDFNSSPA LGNNSPWNSK PPPNAETKSD NPTQQASQ