LDH6B_BOVIN
ID LDH6B_BOVIN Reviewed; 381 AA.
AC Q3T056;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=L-lactate dehydrogenase A-like 6B;
DE EC=1.1.1.27;
GN Name=LDHAL6B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate
CC from pyruvate: step 1/1.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-50 is the initiator.
CC {ECO:0000305}.
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DR EMBL; BC102557; AAI02558.1; -; mRNA.
DR RefSeq; NP_001030352.1; NM_001035275.2.
DR AlphaFoldDB; Q3T056; -.
DR SMR; Q3T056; -.
DR IntAct; Q3T056; 1.
DR PeptideAtlas; Q3T056; -.
DR PRIDE; Q3T056; -.
DR GeneID; 509519; -.
DR KEGG; bta:509519; -.
DR CTD; 92483; -.
DR InParanoid; Q3T056; -.
DR OrthoDB; 1204514at2759; -.
DR UniPathway; UPA00554; UER00611.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004459; F:L-lactate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; -; 1.
DR HAMAP; MF_00488; Lactate_dehydrog; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR011304; L-lactate_DH.
DR InterPro; IPR018177; L-lactate_DH_AS.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF51735; SSF51735; 1.
DR SUPFAM; SSF56327; SSF56327; 1.
DR TIGRFAMs; TIGR01771; L-LDH-NAD; 1.
DR PROSITE; PS00064; L_LDH; 1.
PE 2: Evidence at transcript level;
KW NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1..381
FT /note="L-lactate dehydrogenase A-like 6B"
FT /id="PRO_0000239653"
FT ACT_SITE 242
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 101..106
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 148
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 155
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 187
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 187
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 297
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 381 AA; 41592 MW; B6510C30FD480668 CRC64;
MSWTVGILRA SQRAGTVRAN FLCLGMAPSP CPPAATPLGG AWAVAPASKM ATVKCELMKN
FTSEEPVRNS KISIVGTGSV GMACAVSILL KGLSDELALV DVDEGRLKGE TMDLQHGSLF
VKMPNIVSSR DYVVTANSNL VIITAGARQE KGETRLNLVQ RNVAIFKLMM SSIVQYSPRC
KLIVVSNPVD ILTYVAWKLS AFPQNRVIGS GCNLDTARFR FLIGQRLSIH SESCHGWILG
EHGDSSVPVW SGVNIAGVPL KELNLDIGTD KDPEQWKNVH KDVVASAYEI IKMKGYTYWA
IGLSVADLTE SILKNLRRVH PVSTRIKGLY GINEEVFLSV PCILGESGIT DLIKVKLAPE
EEARLQKSAK TLWDIQKELK F
