LDOC1_HUMAN
ID LDOC1_HUMAN Reviewed; 146 AA.
AC O95751; Q6IAR6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Protein LDOC1;
DE AltName: Full=Leucine zipper protein down-regulated in cancer cells;
GN Name=LDOC1; Synonyms=BCUR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Fetal brain;
RX PubMed=10403563; DOI=10.1016/s0304-3835(99)00087-7;
RA Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K.;
RT "Identification of a novel gene, LDOC1, down-regulated in cancer cell
RT lines.";
RL Cancer Lett. 140:227-234(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH NOD2, AND INDUCTION.
RX PubMed=27812135; DOI=10.1371/journal.pone.0165420;
RA Thiebaut R., Esmiol S., Lecine P., Mahfouz B., Hermant A., Nicoletti C.,
RA Parnis S., Perroy J., Borg J.P., Pascoe L., Hugot J.P., Ollendorff V.;
RT "Characterization and Genetic Analyses of New Genes Coding for NOD2
RT Interacting Proteins.";
RL PLoS ONE 11:E0165420-E0165420(2016).
CC -!- FUNCTION: May have an important role in the development and/or
CC progression of some cancers.
CC -!- SUBUNIT: Interacts with NOD2. {ECO:0000269|PubMed:27812135}.
CC -!- INTERACTION:
CC O95751; O14639: ABLIM1; NbExp=2; IntAct=EBI-740738, EBI-487024;
CC O95751; Q6ZN18-2: AEBP2; NbExp=3; IntAct=EBI-740738, EBI-10255023;
CC O95751; Q9BXS5: AP1M1; NbExp=6; IntAct=EBI-740738, EBI-541426;
CC O95751; P29972: AQP1; NbExp=3; IntAct=EBI-740738, EBI-745213;
CC O95751; P18848: ATF4; NbExp=10; IntAct=EBI-740738, EBI-492498;
CC O95751; O75348: ATP6V1G1; NbExp=4; IntAct=EBI-740738, EBI-711802;
CC O95751; A0AVN2: BARD1; NbExp=3; IntAct=EBI-740738, EBI-9977322;
CC O95751; Q99728: BARD1; NbExp=7; IntAct=EBI-740738, EBI-473181;
CC O95751; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-740738, EBI-745073;
CC O95751; Q13895: BYSL; NbExp=4; IntAct=EBI-740738, EBI-358049;
CC O95751; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-740738, EBI-8643161;
CC O95751; Q99459: CDC5L; NbExp=3; IntAct=EBI-740738, EBI-374880;
CC O95751; Q96M91: CFAP53; NbExp=3; IntAct=EBI-740738, EBI-742422;
CC O95751; Q8WYA6: CTNNBL1; NbExp=4; IntAct=EBI-740738, EBI-748128;
CC O95751; Q92785: DPF2; NbExp=6; IntAct=EBI-740738, EBI-359932;
CC O95751; Q7L190: DPPA4; NbExp=7; IntAct=EBI-740738, EBI-710457;
CC O95751; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-740738, EBI-744099;
CC O95751; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-740738, EBI-1752811;
CC O95751; Q3B820: FAM161A; NbExp=3; IntAct=EBI-740738, EBI-719941;
CC O95751; Q9Y247: FAM50B; NbExp=6; IntAct=EBI-740738, EBI-742802;
CC O95751; Q86YD7: FAM90A1; NbExp=6; IntAct=EBI-740738, EBI-6658203;
CC O95751; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-740738, EBI-11958845;
CC O95751; P15407: FOSL1; NbExp=3; IntAct=EBI-740738, EBI-744510;
CC O95751; P51116: FXR2; NbExp=3; IntAct=EBI-740738, EBI-740459;
CC O95751; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-740738, EBI-372506;
CC O95751; Q9NVN8: GNL3L; NbExp=5; IntAct=EBI-740738, EBI-746682;
CC O95751; O95872: GPANK1; NbExp=3; IntAct=EBI-740738, EBI-751540;
CC O95751; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-740738, EBI-2514791;
CC O95751; P56524: HDAC4; NbExp=3; IntAct=EBI-740738, EBI-308629;
CC O95751; P56524-2: HDAC4; NbExp=3; IntAct=EBI-740738, EBI-11953488;
CC O95751; O14964: HGS; NbExp=10; IntAct=EBI-740738, EBI-740220;
CC O95751; P09067: HOXB5; NbExp=3; IntAct=EBI-740738, EBI-3893317;
CC O95751; P31273: HOXC8; NbExp=3; IntAct=EBI-740738, EBI-1752118;
CC O95751; P42858: HTT; NbExp=5; IntAct=EBI-740738, EBI-466029;
CC O95751; A0A0S2Z3X1: INPP1; NbExp=3; IntAct=EBI-740738, EBI-16430606;
CC O95751; Q15051-2: IQCB1; NbExp=3; IntAct=EBI-740738, EBI-11944935;
CC O95751; O75564-2: JRK; NbExp=3; IntAct=EBI-740738, EBI-17181882;
CC O95751; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-740738, EBI-10253976;
CC O95751; Q96BZ8: LENG1; NbExp=8; IntAct=EBI-740738, EBI-726510;
CC O95751; P25791-3: LMO2; NbExp=3; IntAct=EBI-740738, EBI-11959475;
CC O95751; O95983-2: MBD3; NbExp=3; IntAct=EBI-740738, EBI-11978579;
CC O95751; Q9HAF1: MEAF6; NbExp=3; IntAct=EBI-740738, EBI-399266;
CC O95751; P55081: MFAP1; NbExp=6; IntAct=EBI-740738, EBI-1048159;
CC O95751; A6NI15: MSGN1; NbExp=3; IntAct=EBI-740738, EBI-11991020;
CC O95751; P48552: NRIP1; NbExp=3; IntAct=EBI-740738, EBI-746484;
CC O95751; Q9UBU9: NXF1; NbExp=4; IntAct=EBI-740738, EBI-398874;
CC O95751; Q86TG7: PEG10; NbExp=4; IntAct=EBI-740738, EBI-2858265;
CC O95751; Q86TG7-2: PEG10; NbExp=4; IntAct=EBI-740738, EBI-6259410;
CC O95751; Q9H8W4: PLEKHF2; NbExp=5; IntAct=EBI-740738, EBI-742388;
CC O95751; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-740738, EBI-2557469;
CC O95751; Q99633: PRPF18; NbExp=3; IntAct=EBI-740738, EBI-2798416;
CC O95751; Q8WWY3: PRPF31; NbExp=10; IntAct=EBI-740738, EBI-1567797;
CC O95751; P25786: PSMA1; NbExp=8; IntAct=EBI-740738, EBI-359352;
CC O95751; Q92530: PSMF1; NbExp=3; IntAct=EBI-740738, EBI-945916;
CC O95751; O14966: RAB29; NbExp=4; IntAct=EBI-740738, EBI-372165;
CC O95751; Q6FGU7: RAB7L1; NbExp=3; IntAct=EBI-740738, EBI-10249635;
CC O95751; Q15311: RALBP1; NbExp=3; IntAct=EBI-740738, EBI-749285;
CC O95751; A6NK89: RASSF10; NbExp=3; IntAct=EBI-740738, EBI-6912267;
CC O95751; Q8N443: RIBC1; NbExp=3; IntAct=EBI-740738, EBI-10265323;
CC O95751; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-740738, EBI-16428950;
CC O95751; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-740738, EBI-366570;
CC O95751; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-740738, EBI-748391;
CC O95751; O00560: SDCBP; NbExp=6; IntAct=EBI-740738, EBI-727004;
CC O95751; Q9H788: SH2D4A; NbExp=8; IntAct=EBI-740738, EBI-747035;
CC O95751; Q96GM5: SMARCD1; NbExp=5; IntAct=EBI-740738, EBI-358489;
CC O95751; Q9H7L9: SUDS3; NbExp=3; IntAct=EBI-740738, EBI-540496;
CC O95751; Q5VWN6-2: TASOR2; NbExp=3; IntAct=EBI-740738, EBI-10172380;
CC O95751; Q9P0N9: TBC1D7; NbExp=6; IntAct=EBI-740738, EBI-3258000;
CC O95751; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-740738, EBI-11955057;
CC O95751; Q15561: TEAD4; NbExp=3; IntAct=EBI-740738, EBI-747736;
CC O95751; Q9BT49: THAP7; NbExp=3; IntAct=EBI-740738, EBI-741350;
CC O95751; Q08117: TLE5; NbExp=3; IntAct=EBI-740738, EBI-717810;
CC O95751; Q08117-2: TLE5; NbExp=3; IntAct=EBI-740738, EBI-11741437;
CC O95751; P13805: TNNT1; NbExp=4; IntAct=EBI-740738, EBI-726527;
CC O95751; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-740738, EBI-10241197;
CC O95751; Q99598: TSNAX; NbExp=3; IntAct=EBI-740738, EBI-742638;
CC O95751; Q5W5X9: TTC23; NbExp=4; IntAct=EBI-740738, EBI-6447954;
CC O95751; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-740738, EBI-9090990;
CC O95751; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-740738, EBI-17208936;
CC O95751; Q9BVJ6: UTP14A; NbExp=3; IntAct=EBI-740738, EBI-473284;
CC O95751; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-740738, EBI-12032042;
CC O95751; Q05516: ZBTB16; NbExp=4; IntAct=EBI-740738, EBI-711925;
CC O95751; O43167: ZBTB24; NbExp=7; IntAct=EBI-740738, EBI-744471;
CC O95751; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-740738, EBI-2555749;
CC O95751; Q8N5A5: ZGPAT; NbExp=5; IntAct=EBI-740738, EBI-3439227;
CC O95751; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-740738, EBI-10183064;
CC O95751; Q15973: ZNF124; NbExp=3; IntAct=EBI-740738, EBI-2555767;
CC O95751; P15622-3: ZNF250; NbExp=3; IntAct=EBI-740738, EBI-10177272;
CC O95751; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-740738, EBI-347633;
CC O95751; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-740738, EBI-10273713;
CC O95751; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-740738, EBI-6427977;
CC O95751; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-740738, EBI-9977294;
CC O95751; Q5T619: ZNF648; NbExp=3; IntAct=EBI-740738, EBI-11985915;
CC O95751; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-740738, EBI-16429014;
CC O95751; Q6NX45: ZNF774; NbExp=5; IntAct=EBI-740738, EBI-10251462;
CC O95751; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-740738, EBI-5667516;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10403563}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with high levels in brain
CC ant thyroid and low expression in placenta, liver and leukocytes.
CC Expressed as well in six of the seven human breast cancer cell lines
CC examined. {ECO:0000269|PubMed:10403563}.
CC -!- INDUCTION: Down-regulated by muramyl-dipeptide and lipopolysaccharide.
CC {ECO:0000269|PubMed:27812135}.
CC -!- SIMILARITY: Belongs to the LDOC1 family. {ECO:0000305}.
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DR EMBL; AB019527; BAA34364.1; -; mRNA.
DR EMBL; CR457088; CAG33369.1; -; mRNA.
DR EMBL; AL109799; CAC18891.1; -; Genomic_DNA.
DR EMBL; BC003104; AAH03104.1; -; mRNA.
DR CCDS; CCDS14672.1; -.
DR RefSeq; NP_036449.1; NM_012317.3.
DR AlphaFoldDB; O95751; -.
DR SMR; O95751; -.
DR BioGRID; 117169; 122.
DR IntAct; O95751; 118.
DR MINT; O95751; -.
DR STRING; 9606.ENSP00000359557; -.
DR BioMuta; LDOC1; -.
DR EPD; O95751; -.
DR MassIVE; O95751; -.
DR MaxQB; O95751; -.
DR PaxDb; O95751; -.
DR PeptideAtlas; O95751; -.
DR PRIDE; O95751; -.
DR ProteomicsDB; 51022; -.
DR Antibodypedia; 16816; 208 antibodies from 26 providers.
DR DNASU; 23641; -.
DR Ensembl; ENST00000370526.5; ENSP00000359557.2; ENSG00000182195.9.
DR GeneID; 23641; -.
DR KEGG; hsa:23641; -.
DR MANE-Select; ENST00000370526.5; ENSP00000359557.2; NM_012317.4; NP_036449.1.
DR UCSC; uc004fbj.5; human.
DR CTD; 23641; -.
DR DisGeNET; 23641; -.
DR GeneCards; LDOC1; -.
DR HGNC; HGNC:6548; LDOC1.
DR HPA; ENSG00000182195; Tissue enhanced (pituitary).
DR MIM; 300402; gene.
DR neXtProt; NX_O95751; -.
DR OpenTargets; ENSG00000182195; -.
DR PharmGKB; PA30329; -.
DR VEuPathDB; HostDB:ENSG00000182195; -.
DR eggNOG; ENOG502T19P; Eukaryota.
DR GeneTree; ENSGT00940000162721; -.
DR HOGENOM; CLU_154949_0_0_1; -.
DR InParanoid; O95751; -.
DR OMA; QTTSYML; -.
DR OrthoDB; 1526235at2759; -.
DR PhylomeDB; O95751; -.
DR TreeFam; TF337843; -.
DR PathwayCommons; O95751; -.
DR SignaLink; O95751; -.
DR BioGRID-ORCS; 23641; 8 hits in 699 CRISPR screens.
DR ChiTaRS; LDOC1; human.
DR GeneWiki; LDOC1; -.
DR GenomeRNAi; 23641; -.
DR Pharos; O95751; Tbio.
DR PRO; PR:O95751; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O95751; protein.
DR Bgee; ENSG00000182195; Expressed in descending thoracic aorta and 191 other tissues.
DR Genevisible; O95751; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:UniProtKB.
DR GO; GO:0071225; P:cellular response to muramyl dipeptide; IMP:UniProtKB.
DR GO; GO:0001893; P:maternal placenta development; IEA:Ensembl.
DR GO; GO:0060137; P:maternal process involved in parturition; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; TAS:ProtInc.
DR GO; GO:1903547; P:regulation of growth hormone activity; IEA:Ensembl.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR PANTHER; PTHR15503; PTHR15503; 1.
DR Pfam; PF16297; DUF4939; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..146
FT /note="Protein LDOC1"
FT /id="PRO_0000084391"
SQ SEQUENCE 146 AA; 16968 MW; 3D02813B2DE52DBE CRC64;
MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP VPFPETFNGE
SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA EEWVVPYIEM DSPILGDYRA
FLDEMKQCFG WDDDEDDDDE EEEDDY
