LDP1_CAEEL
ID LDP1_CAEEL Reviewed; 426 AA.
AC Q9GZE9; Q8IA58;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Lipid droplet localized protein {ECO:0000312|WormBase:F22F7.1a};
GN Name=ldp-1 {ECO:0000312|WormBase:F22F7.1a};
GN ORFNames=F22F7.1 {ECO:0000312|WormBase:F22F7.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=26121959; DOI=10.1016/j.bbalip.2015.06.004;
RA Vrablik T.L., Petyuk V.A., Larson E.M., Smith R.D., Watts J.L.;
RT "Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets
RT and identification of ACS-4 as a lipid droplet-associated protein.";
RL Biochim. Biophys. Acta 1851:1337-1345(2015).
RN [3] {ECO:0000305}
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=26025681; DOI=10.1016/j.bbamcr.2015.05.020;
RA Na H., Zhang P., Chen Y., Zhu X., Liu Y., Liu Y., Xie K., Xu N., Yang F.,
RA Yu Y., Cichello S., Mak H.Y., Wang M.C., Zhang H., Liu P.;
RT "Identification of lipid droplet structure-like/resident proteins in
RT Caenorhabditis elegans.";
RL Biochim. Biophys. Acta 1853:2481-2491(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:26025681,
CC ECO:0000269|PubMed:26121959}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:F22F7.1a};
CC IsoId=Q9GZE9-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F22F7.1b};
CC IsoId=Q9GZE9-2; Sequence=VSP_059216;
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; BX284605; CCD67439.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD67440.2; -; Genomic_DNA.
DR PIR; T33187; T33187.
DR RefSeq; NP_503577.1; NM_071176.4. [Q9GZE9-1]
DR RefSeq; NP_872194.2; NM_182394.5. [Q9GZE9-2]
DR AlphaFoldDB; Q9GZE9; -.
DR DIP; DIP-26138N; -.
DR STRING; 6239.F22F7.1a; -.
DR EPD; Q9GZE9; -.
DR PaxDb; Q9GZE9; -.
DR PeptideAtlas; Q9GZE9; -.
DR EnsemblMetazoa; F22F7.1a.1; F22F7.1a.1; WBGene00017719. [Q9GZE9-1]
DR EnsemblMetazoa; F22F7.1b.1; F22F7.1b.1; WBGene00017719. [Q9GZE9-2]
DR GeneID; 178692; -.
DR KEGG; cel:CELE_F22F7.1; -.
DR UCSC; F22F7.1a.1; c. elegans.
DR CTD; 178692; -.
DR WormBase; F22F7.1a; CE17691; WBGene00017719; ldp-1. [Q9GZE9-1]
DR WormBase; F22F7.1b; CE51032; WBGene00017719; ldp-1. [Q9GZE9-2]
DR eggNOG; KOG2733; Eukaryota.
DR GeneTree; ENSGT00390000004799; -.
DR InParanoid; Q9GZE9; -.
DR OMA; RTYFKMT; -.
DR OrthoDB; 887497at2759; -.
DR PhylomeDB; Q9GZE9; -.
DR Reactome; R-CEL-114608; Platelet degranulation.
DR PRO; PR:Q9GZE9; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017719; Expressed in larva and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipid droplet; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..426
FT /note="Lipid droplet localized protein"
FT /evidence="ECO:0000305"
FT /id="PRO_0000442241"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_059216"
SQ SEQUENCE 426 AA; 47294 MW; 4D9E6E891D6BB16A CRC64;
MSRYDVVVYG ASGFTGAYVV EYLVNSEQFE GLSFAVAGRS EKKLREVLRN ISQKTGKDVS
NAAVIVADSA DERSLNEMAR QANVVINAVG PYRLYGEAVV KAAVENGASH VDISGEPAWI
EKMQQKYSKQ AKEQGVYVVS ACGWDSIPAD LGVNFLKKNF HGDLNHVESF VQLLTGPSGY
SFNAGTYQTL ILGLSGAATD KLGAVRKEIM PEKIVRGAVK LPKRPTLWEI KEKELNGVAV
PFPGADKSII NRSQYYDATS RQVRPIHMET YIRLSSQFYG YLIGLWIMFL SIFVKYPFTR
RILQQYPDQC SFYMFKNSGP SARQMAEASF VYWFFGYGYK ETLPLDQQHE GKINRKVLAT
CKGPDAGYIA TSGCVLSAAL TLIRDKDNLP KDGGVYTTAA AFGNSKIYDY LASFGITYQL
ESEYDL
