LDRC_ECOLI
ID LDRC_ECOLI Reviewed; 35 AA.
AC P0DPD1; Q2MBG4; Q6BF86;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2017, sequence version 1.
DT 03-AUG-2022, entry version 18.
DE RecName: Full=Small toxic polypeptide LdrC;
GN Name=ldrC; OrderedLocusNames=b4423, JW5959;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=12123448; DOI=10.1046/j.1365-2958.2002.03042.x;
RA Kawano M., Oshima T., Kasai H., Mori H.;
RT "Molecular characterization of long direct repeat (LDR) sequences
RT expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide
RT and a cis-encoded small antisense RNA in Escherichia coli.";
RL Mol. Microbiol. 45:333-349(2002).
CC -!- FUNCTION: Toxic component of a type I toxin-antitoxin (TA) system.
CC Overexpression causes rapid cell killing, probably by disrupting the
CC cell inner membrane and disruption of ATP synthesis.
CC {ECO:0000250|UniProtKB:P0DPD0}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0DPD0}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Expression of the proteinaceous toxin is probably controlled
CC by an antisense sRNA, in this case RdlC. Only a few of these TA systems
CC have been mechanistically characterized; the mechanisms used to control
CC expression of the toxin gene are not necessarily the same (Probable).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Ldr toxic peptide family. {ECO:0000305}.
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DR EMBL; U00096; AAT48128.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76394.1; -; Genomic_DNA.
DR RefSeq; WP_000170955.1; NZ_SSZK01000010.1.
DR RefSeq; YP_025297.1; NC_000913.3.
DR RefSeq; YP_025299.1; NC_000913.3.
DR AlphaFoldDB; P0DPD1; -.
DR SMR; P0DPD1; -.
DR EnsemblBacteria; AAT48128; AAT48128; b4423.
DR EnsemblBacteria; BAE76394; BAE76394; BAE76394.
DR GeneID; 2847733; -.
DR GeneID; 2847775; -.
DR GeneID; 58460425; -.
DR KEGG; ecj:JW5959; -.
DR KEGG; eco:b4419; -.
DR KEGG; eco:b4423; -.
DR HOGENOM; CLU_212598_1_0_6; -.
DR BioCyc; EcoCyc:MON0-1603; -.
DR PRO; PR:P0DPD1; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR025253; Toxin_Ldr.
DR Pfam; PF13940; Ldr_toxin; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT PEPTIDE 1..35
FT /note="Small toxic polypeptide LdrC"
FT /id="PRO_0000442720"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 35 AA; 4014 MW; 5C87B0B2BC271596 CRC64;
MTLAQFAMIF WHDLAAPILA GIITAAIVSW WRNRK
