LDRP_THET2
ID LDRP_THET2 Reviewed; 195 AA.
AC Q746J8;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Transcriptional regulator LdrP {ECO:0000303|PubMed:25294106};
DE AltName: Full=Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein LdrP {ECO:0000303|PubMed:21421762, ECO:0000303|PubMed:25294106};
DE Short=CRP/FNR superfamily protein LdrP {ECO:0000303|PubMed:21421762, ECO:0000303|PubMed:25294106};
DE AltName: Full=Light induced transcription regulator-dependent regulatory protein {ECO:0000303|PubMed:21421762};
DE AltName: Full=LitR-dependent regulatory protein {ECO:0000303|PubMed:25294106};
DE Short=LdrP {ECO:0000303|PubMed:25294106};
GN OrderedLocusNames=TT_P0055 {ECO:0000312|EMBL:AAS82385.1};
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OG Plasmid pTT27 {ECO:0000312|EMBL:AAS82385.1,
OG ECO:0000312|Proteomes:UP000000592}.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724 {ECO:0000312|EMBL:AAS82385.1};
RN [1] {ECO:0000312|EMBL:AAS82385.1, ECO:0000312|Proteomes:UP000000592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27 {ECO:0000312|Proteomes:UP000000592};
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27 {ECO:0000303|PubMed:21421762};
RX PubMed=21421762; DOI=10.1128/jb.01125-10;
RA Takano H., Kondo M., Usui N., Usui T., Ohzeki H., Yamazaki R., Washioka M.,
RA Nakamura A., Hoshino T., Hakamata W., Beppu T., Ueda K.;
RT "Involvement of CarA/LitR and CRP/FNR family transcriptional regulators in
RT light-induced carotenoid production in Thermus thermophilus.";
RL J. Bacteriol. 193:2451-2459(2011).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27 {ECO:0000303|PubMed:25294106};
RX PubMed=25294106; DOI=10.1099/mic.0.082263-0;
RA Takano H., Agari Y., Hagiwara K., Watanabe R., Yamazaki R., Beppu T.,
RA Shinkai A., Ueda K.;
RT "LdrP, a cAMP receptor protein/FNR family transcriptional regulator, serves
RT as a positive regulator for the light-inducible gene cluster in the
RT megaplasmid of Thermus thermophilus.";
RL Microbiology 160:2650-2660(2014).
CC -!- FUNCTION: Activates transcription. Positively regulates PcrtB promoter
CC upstream of the crtB operon in a cAMP-independent manner. Regulated
CC genes include genes encoding DNA photolyase, phytoene synthase and
CC cytochrome P450 monooxygenase, which are involved in carotenoid
CC biosynthesis (PubMed:21421762). Positively regulates the light-
CC inducible gene cluster in the megaplasmid in a cAMP-independent manner
CC (PubMed:25294106). {ECO:0000269|PubMed:21421762,
CC ECO:0000269|PubMed:25294106}.
CC -!- DISRUPTION PHENOTYPE: No production of carotenoids in dark or light
CC conditions (PubMed:21421762). Does not activate expression of TT_P0044,
CC TT_P0049 or TT_P0070 in dark or light conditions (PubMed:25294106).
CC {ECO:0000269|PubMed:21421762, ECO:0000269|PubMed:25294106}.
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DR EMBL; AE017222; AAS82385.1; -; Genomic_DNA.
DR RefSeq; WP_011174504.1; NC_005838.1.
DR AlphaFoldDB; Q746J8; -.
DR SMR; Q746J8; -.
DR STRING; 262724.TT_P0055; -.
DR EnsemblBacteria; AAS82385; AAS82385; TT_P0055.
DR KEGG; tth:TT_P0055; -.
DR eggNOG; COG0664; Bacteria.
DR HOGENOM; CLU_075053_3_1_0; -.
DR OMA; PRAMDHE; -.
DR OrthoDB; 1596937at2; -.
DR Proteomes; UP000000592; Plasmid pTT27.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0071482; P:cellular response to light stimulus; IDA:UniProtKB.
DR GO; GO:1904143; P:positive regulation of carotenoid biosynthetic process; IMP:UniProtKB.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR012318; HTH_CRP.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF13545; HTH_Crp_2; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00419; HTH_CRP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS51063; HTH_CRP_2; 1.
PE 4: Predicted;
KW DNA-binding; Plasmid; Transcription; Transcription regulation.
FT CHAIN 1..195
FT /note="Transcriptional regulator LdrP"
FT /id="PRO_0000436260"
FT DOMAIN 110..182
FT /note="HTH crp-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT DNA_BIND 142..161
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
SQ SEQUENCE 195 AA; 22124 MW; 81A80BA5CA186AB1 CRC64;
MKRFARKETI YLRGEEARTL YRLEEGLVRV VELLPDGRLI TLRHVLPGDY FGEEALEGKA
YRYTAEAMTE AVVQGLDPRA MDHEALHRVA RNLARQMRRV QAYEAHLQTG ELRARIARYL
LFLADTPLSA RDRQGIYVTV SHEEIADATA SIRESVSKVL ADLRREGLIA TAYRRVYLLD
LAALEREAGS ALEAA
