LE607_CAEEL
ID LE607_CAEEL Reviewed; 690 AA.
AC O44743;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=CREB-H transcription factor homolog let-607 {ECO:0000303|PubMed:24811939};
DE AltName: Full=Lethal 607 protein {ECO:0000312|WormBase:F57B10.1};
GN Name=let-607 {ECO:0000312|WormBase:F57B10.1};
GN ORFNames=F57B10.1 {ECO:0000312|WormBase:F57B10.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=24811939; DOI=10.1002/dvdy.24146;
RA Wong M.C., Kennedy W.P., Schwarzbauer J.E.;
RT "Transcriptionally regulated cell adhesion network dictates distal tip cell
RT directionality.";
RL Dev. Dyn. 243:999-1010(2014).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27510972; DOI=10.1242/dev.140046;
RA Weicksel S.E., Mahadav A., Moyle M., Cipriani P.G., Kudron M., Pincus Z.,
RA Bahmanyar S., Abriola L., Merkel J., Gutwein M., Fernandez A.G., Piano F.,
RA Gunsalus K.C., Reinke V.;
RT "A novel small molecule that disrupts a key event during the oocyte-to-
RT embryo transition in C. elegans.";
RL Development 143:3540-3548(2016).
CC -!- FUNCTION: Probable transcription factor, required during migration of
CC the gonadal distal tip cells (DTC) (PubMed:24811939). Probably
CC regulates cell adhesion of DTCs via modulation of expression of genes
CC involved in integrin-mediated adhesion, including tln-1, src-1, and
CC integrin pat-2 (PubMed:24811939). Modulates expression of genes
CC involved in protein trafficking during embryogenesis, including emo-1,
CC sec-61, calu-1, sec-24.1, enpl-1, sar-1 and tfg-1 (PubMed:27510972).
CC {ECO:0000269|PubMed:24811939, ECO:0000269|PubMed:27510972}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the gonadal distal tip cells (DTC)
CC during larval stages L2, L3 and L4. {ECO:0000269|PubMed:24811939}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown targeted to the gonadal
CC distal tip cells (DTC) causes DTC migration defects (PubMed:24811939).
CC Significant reduction in expression of src-1 and tln-1 in DTCs
CC (PubMed:24811939). Causes slow growth after hatching (PubMed:27510972).
CC {ECO:0000269|PubMed:24811939, ECO:0000269|PubMed:27510972}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BX284601; CCD71470.1; -; Genomic_DNA.
DR PIR; T32750; T32750.
DR RefSeq; NP_491897.2; NM_059496.6.
DR AlphaFoldDB; O44743; -.
DR SMR; O44743; -.
DR IntAct; O44743; 4.
DR STRING; 6239.F57B10.1.1; -.
DR EPD; O44743; -.
DR PaxDb; O44743; -.
DR PeptideAtlas; O44743; -.
DR EnsemblMetazoa; F57B10.1.1; F57B10.1.1; WBGene00002783.
DR EnsemblMetazoa; F57B10.1.2; F57B10.1.2; WBGene00002783.
DR GeneID; 266837; -.
DR KEGG; cel:CELE_F57B10.1; -.
DR UCSC; F57B10.1.1; c. elegans.
DR CTD; 266837; -.
DR WormBase; F57B10.1; CE37244; WBGene00002783; let-607.
DR eggNOG; KOG0709; Eukaryota.
DR HOGENOM; CLU_401277_0_0_1; -.
DR InParanoid; O44743; -.
DR OMA; FEDQCDA; -.
DR OrthoDB; 1007856at2759; -.
DR Reactome; R-CEL-8874211; CREB3 factors activate genes.
DR SignaLink; O44743; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002783; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0000785; C:chromatin; IMP:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:UniProtKB.
DR GO; GO:0090038; P:negative regulation of protein kinase C signaling; IGI:WormBase.
DR GO; GO:0008361; P:regulation of cell size; IMP:WormBase.
DR GO; GO:1903354; P:regulation of distal tip cell migration; IMP:UniProtKB.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IGI:WormBase.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..690
FT /note="CREB-H transcription factor homolog let-607"
FT /id="PRO_0000452349"
FT DOMAIN 284..347
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 87..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..321
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 326..333
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 451..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..350
FT /evidence="ECO:0000255"
FT COMPBIAS 91..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 75901 MW; C3344DD9D95F0AA8 CRC64;
MDQDFDLDEG AGQFNLKTTL MMFTSNDSQN DDGIWSPGSP YQALEDPSFL DKHFVSDPDR
YTADELYSAL EKMDGKSDLI GMDDMDNDNC YSLSPPDSGS LPISPASTSP SSYHSSGGED
LMDCYPSIDI LQQASEELLY SKDDDYEICS SGPLLAYTNA NSVATSAVHQ NQQQQQRRLN
QAGFPHQNSN GLVRFKSSQP RVLNPASISL NAPSSSFNPQ STSSTPATSS SSSSSTNGGF
VKSSTGERRK YPPLRLDEEE IKLCKKEGIC LPDFFPLTKA EERDLKRIRR KIRNKRSAQT
SRKRKQDYIE QLEDRVSEST KENQALKQQI ERLSSENQSV ISQLKKLQAQ LGQNAKRTTQ
AGRCLAVFML SACLLVSPQL SPLGNQDNQK VLECIEEACQ PSATSMNSAN SAQRAIAGVT
APSVVIPSGG PVMVSTNANR QMNRNAVLNH HNNSKYPASG NQNHHPIALE DLNHPPPTLQ
PKQSYQQQHQ PSMYRRSDET IAMAMAKIGA RKGSSTSSSS ASSVASSTST SSATSPIYRT
SRTLGAFEDQ CDASSDDSNC ANMPSLVPMK MSAQPPKRKI VTMNGQPRVT YRAVPASSVN
VEQAQYYKVP QQKVQYVTMD RPIKYEVLQL NDYIKMEEES TIRLPNSWST AGPRLHPQVN
ASSRTVRPLT VATPVHYNGP SAKKIKTQMF
