ID   AREA_ASPNG              Reviewed;         882 AA.
AC   O13412;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Nitrogen regulatory protein areA;
GN   Name=areA;
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=5061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9089 / N402;
RX   PubMed=9540832; DOI=10.1016/s0167-4781(97)00212-1;
RA   MacCabe A.P., Vanhanen S.A.S., Sollewijn Gelpke M., Van de Vondervoort P.,
RA   Arst H.N. Jr., Visser J.;
RT   "Identification, cloning and sequence of the Aspergillus niger areA wide
RT   domain regulatory gene controlling nitrogen utilisation.";
RL   Biochim. Biophys. Acta 1396:163-168(1998).
CC   -!- FUNCTION: Major nitrogen regulatory protein. Positively acting
CC       regulatory gene of nitrogen metabolite repression.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X81998; CAA57524.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13412; -.
DR   STRING; 5061.CADANGAP00010130; -.
DR   PRIDE; O13412; -.
DR   VEuPathDB; FungiDB:An12g08960; -.
DR   VEuPathDB; FungiDB:ASPNIDRAFT2_1209176; -.
DR   VEuPathDB; FungiDB:ATCC64974_34540; -.
DR   VEuPathDB; FungiDB:M747DRAFT_340105; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR013860; AreA_GATA.
DR   InterPro; IPR011420; AreA_N.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 2.
DR   Pfam; PF07573; AreA_N; 1.
DR   Pfam; PF08550; DUF1752; 1.
DR   Pfam; PF00320; GATA; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nitrate assimilation; Nucleus;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..882
FT                   /note="Nitrogen regulatory protein areA"
FT                   /id="PRO_0000083463"
FT   ZN_FING         676..700
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..871
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..604
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..675
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        793..814
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..829
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   882 AA;  94518 MW;  97A502936B94E5AE CRC64;
     MSGLTLGGGG SGGVRPTQPA AFASLQDSAD ADRRSSTTTS NNPPPLPSDF SQLSDDFSFG
     SPISPPHSSN APDSLLHDSL FPEWKVGTPR AGFDGPDEMQ RKDPLATQIW KLYSRTKAQL
     PNQERMENLT WRMMAMSLKR KERERAQQSR SASARNSVSG PSGIAQLTSP PLIASRPTRQ
     NPSLSTDLTS DPMNLERIFI VPFESPSDHP SPQLTKGEAT SAAIPIKSRK DQVAESTPVP
     ASFPHPPQDQ RKNSEFGYVP RRVRKTSIDD RQFFNLQVPT RKRPAEASPQ VPPVSNAMLA
     QDPDLSGGVP DYALDASSAF ALHHNNHSSS HHNHTSPGMP FGLDTYGLGE DPILTSAGPY
     QTQFTFSPTE SPMTSGNPFA NLYAHTPVAS SLNSTDFFSP PQSGYQSTAS TPQPAYDGEH
     SMFFDMPSVD ARTQRRVPNY VSHRTSNLSA SLQPRYMFNQ NQDQSHHTGN HSSSMHSPGY
     PIPQPQHVDP TQVLNPNDFS TGASHAAMFS FGADSDNEDD DGNQFSDRAG LTMPGDLDDG
     ADMNGGMQWD AQFPGSFHSL PGFTAQHRKH VTIGPTDMMD TPSEWAQSGS LGRTHGSAAS
     VSEVRNREQD PRRQKIARTT STPNTAQLLR QSMNANTSHT SPNTPPESGL SSAVPSRPAS
     PGGSKNGEQS SGPTTCTNCF TQTTPLWRRN PEGQPLCNAC GLFLKLHGVV RPLSLKTDVI
     KKRNRSSANS LAVGTSRASK KSARKNSVQQ TTVTTPTSSR AQSGATSFGV RRPRAGAVRR
     AEPLVPIAAA PPKANPTTSS PGQSRGTSSV QMAPKRQRRL EKATDAEAGG DEASKSSTAS
     GGRSKVVALA PAMPPAAANP ANHSIAGGQG ASQEWEWLTM SL