ID   LEAD_ADE02              Reviewed;         145 AA.
AC   P03263;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=I-leader protein;
OS   Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=10515;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6281734; DOI=10.1093/nar/10.8.2539;
RA   Virtanen A., Alestroem P., Persson H., Katze M.G., Pettersson U.;
RT   "An adenovirus agnogene.";
RL   Nucleic Acids Res. 10:2539-2548(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7142161; DOI=10.1016/s0021-9258(18)33473-2;
RA   Gingeras T.R., Sciaky D., Gelinas R.E., Bing-Dong J., Yen C.E., Kelly M.M.,
RA   Bullock P.A., Parsons B.L., O'Neill K.E., Roberts R.J.;
RT   "Nucleotide sequences from the adenovirus-2 genome.";
RL   J. Biol. Chem. 257:13475-13491(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7142162; DOI=10.1016/s0021-9258(18)33474-4;
RA   Alestroem P., Akusjaervi G., Pettersson M., Pettersson U.;
RT   "DNA sequence analysis of the region encoding the terminal protein and the
RT   hypothetical N-gene product of adenovirus type 2.";
RL   J. Biol. Chem. 257:13492-13498(1982).
RN   [4]
RP   IDENTIFICATION, INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=3005631; DOI=10.1128/jvi.57.3.848-856.1986;
RA   Symington J.S., Lucher L.A., Brackmann K.H., Virtanen A., Pettersson U.,
RA   Green M.;
RT   "Biosynthesis of adenovirus type 2 i-leader protein.";
RL   J. Virol. 57:848-856(1986).
RN   [5]
RP   IDENTIFICATION.
RC   STRAIN=Human adenovirus C serotype 5;
RX   PubMed=23142869; DOI=10.1038/nmeth.2227;
RA   Evans V.C., Barker G., Heesom K.J., Fan J., Bessant C., Matthews D.A.;
RT   "De novo derivation of proteomes from transcriptomes for transcript and
RT   protein identification.";
RL   Nat. Methods 9:1207-1211(2012).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000269|PubMed:3005631}. Note=Might be loosely associated with the
CC       nuclear membrane.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle. {ECO:0000305|PubMed:3005631}.
CC   -!- MISCELLANEOUS: Expressed from the major late promoter (MLP) and
CC       produced by alternative splicing. Only protein expressed from the MLP
CC       during the intermediate phase. In the late phase, this region is
CC       spliced to allow expression of all late proteins.
CC   -!- MISCELLANEOUS: Very stable protein with a low turnover rate.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA92207.1; Type=Miscellaneous discrepancy; Note=The last 5 amino acids (C-terminus) are possibly generated by alternative splicing.; Evidence={ECO:0000305};
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DR   EMBL; J01917; AAA92207.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A93421; DQAD62.
DR   RefSeq; NP_040517.2; NC_001405.1.
DR   GeneID; 2652993; -.
DR   Proteomes; UP000008167; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004292; L1-like.
DR   Pfam; PF03052; Adeno_52K; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Reference proteome.
FT   CHAIN           1..145
FT                   /note="I-leader protein"
FT                   /id="PRO_0000221687"
SQ   SEQUENCE   145 AA;  16102 MW;  201886A95A151017 CRC64;
     MRADREELDL PPPVGGVAVD VVKVEVPATG RTLVLAFVKT CAVLAAVHGL YILHEVDLTT
     AHKEAEWEFE PLAWRVWLVV FYFGCLSLTV WLLEGSYGGS DHHAARAQSP DVRARRSELD
     DNIAQMGAVH GLELPRRQVL RHRGT