ID   LEAD_ADE05              Reviewed;         145 AA.
AC   Q2KS19;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 2.
DT   10-FEB-2021, entry version 26.
DE   RecName: Full=I-leader protein;
OS   Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus.
OX   NCBI_TaxID=28285;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1727603; DOI=10.1016/0042-6822(92)90082-z;
RA   Chroboczek J., Bieber F., Jacrot B.;
RT   "The sequence of the genome of adenovirus type 5 and its comparison with
RT   the genome of adenovirus type 2.";
RL   Virology 186:280-285(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate NHRC Ad5FS 7151;
RX   PubMed=16481660; DOI=10.1101/gr.4337206;
RA   Lin B., Wang Z., Vora G.J., Thornton J.A., Schnur J.M., Thach D.C.,
RA   Blaney K.M., Ligler A.G., Malanoski A.P., Santiago J., Walter E.A.,
RA   Agan B.K., Metzgar D., Seto D., Daum L.T., Kruzelock R., Rowley R.K.,
RA   Hanson E.H., Tibbetts C., Stenger D.A.;
RT   "Broad-spectrum respiratory tract pathogen identification using
RT   resequencing DNA microarrays.";
RL   Genome Res. 16:527-535(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=23142869; DOI=10.1038/nmeth.2227;
RA   Evans V.C., Barker G., Heesom K.J., Fan J., Bessant C., Matthews D.A.;
RT   "De novo derivation of proteomes from transcriptomes for transcript and
RT   protein identification.";
RL   Nat. Methods 9:1207-1211(2012).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region.
CC       Note=Might be loosely associated with the nuclear membrane.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Very stable protein with a low turnover rate.
CC   -!- SIMILARITY: Belongs to the adenoviridae leader protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW65503.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY601635; AAW65503.1; ALT_SEQ; Genomic_DNA.
DR   Proteomes; UP000125273; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004292; L1-like.
DR   Pfam; PF03052; Adeno_52K; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm.
FT   CHAIN           1..145
FT                   /note="I-leader protein"
FT                   /id="PRO_0000421135"
SQ   SEQUENCE   145 AA;  16150 MW;  329025B69B978D87 CRC64;
     MRADREELDL PPPIGGVAID VVKVEVPATG RTLVLAFVKT CAVLAAVHGL YILHEVDLTT
     AHKEAEWEFE PLAWRVWLVV FYFGCLSLTV WLLEGSYGGS DHHAARAQSP DVRARRSELD
     DNIAQMGAVH GLELPRRQVL RRRGT