ID   LEAP2_BOVIN             Reviewed;          77 AA.
AC   Q95JC3; Q32P98;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Liver-expressed antimicrobial peptide 2;
DE            Short=LEAP-2;
DE   Flags: Precursor;
GN   Name=LEAP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=12493837; DOI=10.1110/ps.0213603;
RA   Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA   Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA   Wattler F., Wattler S., Adermann K.;
RT   "Isolation and biochemical characterization of LEAP-2, a novel blood
RT   peptide expressed in the liver.";
RL   Protein Sci. 12:143-152(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has an antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR   EMBL; AJ409014; CAC51470.1; -; mRNA.
DR   EMBL; BC108204; AAI08205.1; -; mRNA.
DR   RefSeq; NP_776984.1; NM_174559.4.
DR   AlphaFoldDB; Q95JC3; -.
DR   SMR; Q95JC3; -.
DR   STRING; 9913.ENSBTAP00000025186; -.
DR   PaxDb; Q95JC3; -.
DR   Ensembl; ENSBTAT00000025186; ENSBTAP00000025186; ENSBTAG00000018926.
DR   GeneID; 282270; -.
DR   KEGG; bta:282270; -.
DR   CTD; 116842; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018926; -.
DR   VGNC; VGNC:30831; LEAP2.
DR   eggNOG; ENOG502SD5B; Eukaryota.
DR   GeneTree; ENSGT00390000013467; -.
DR   HOGENOM; CLU_178163_0_0_1; -.
DR   InParanoid; Q95JC3; -.
DR   OMA; SRRMTPF; -.
DR   OrthoDB; 1622785at2759; -.
DR   TreeFam; TF336274; -.
DR   Reactome; R-BTA-6803157; Antimicrobial peptides.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000018926; Expressed in liver and 88 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR009955; LEAP-2.
DR   PANTHER; PTHR21007; PTHR21007; 1.
DR   Pfam; PF07359; LEAP-2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..37
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000017351"
FT   CHAIN           38..77
FT                   /note="Liver-expressed antimicrobial peptide 2"
FT                   /id="PRO_0000017352"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8856 MW;  BB70BB721F0B25B8 CRC64;
     MWHLKLFAVL MICLLLLAQV DGSPIPQQSS AKRRPRRMTP FWRAVSLRPI GASCRDDSEC
     ITRLCRKRRC SLSVAQE