LEAP2_CAVPO
ID LEAP2_CAVPO Reviewed; 71 AA.
AC Q91X13;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Liver-expressed antimicrobial peptide 2;
DE Short=LEAP-2;
DE Flags: Precursor; Fragment;
GN Name=LEAP2;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RX PubMed=12493837; DOI=10.1110/ps.0213603;
RA Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA Wattler F., Wattler S., Adermann K.;
RT "Isolation and biochemical characterization of LEAP-2, a novel blood
RT peptide expressed in the liver.";
RL Protein Sci. 12:143-152(2003).
CC -!- FUNCTION: Has an antimicrobial activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR EMBL; AJ409054; CAC51471.1; -; mRNA.
DR AlphaFoldDB; Q91X13; -.
DR SMR; Q91X13; -.
DR STRING; 10141.ENSCPOP00000021028; -.
DR eggNOG; ENOG502SD5B; Eukaryota.
DR HOGENOM; CLU_178163_0_0_1; -.
DR InParanoid; Q91X13; -.
DR OMA; SRRMTPF; -.
DR TreeFam; TF336274; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR009955; LEAP-2.
DR PANTHER; PTHR21007; PTHR21007; 1.
DR Pfam; PF07359; LEAP-2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL <1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..31
FT /evidence="ECO:0000255"
FT /id="PRO_0000017353"
FT CHAIN 32..71
FT /note="Liver-expressed antimicrobial peptide 2"
FT /id="PRO_0000017354"
FT DISULFID 48..59
FT /evidence="ECO:0000250"
FT DISULFID 54..64
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 71 AA; 7943 MW; 1F23ED8495183644 CRC64;
SVVLLICLLL LGQVDGSPVP EKSSVKKRLR RMTPFWRGVS LRPIGASCRD DSECITRLCK
KRRCSLSVAQ E