LEAP2_HUMAN
ID LEAP2_HUMAN Reviewed; 77 AA.
AC Q969E1; D3DQ91;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Liver-expressed antimicrobial peptide 2;
DE Short=LEAP-2;
DE Flags: Precursor;
GN Name=LEAP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DISULFIDE BONDS.
RC TISSUE=Liver, and Lung;
RX PubMed=12493837; DOI=10.1110/ps.0213603;
RA Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA Wattler F., Wattler S., Adermann K.;
RT "Isolation and biochemical characterization of LEAP-2, a novel blood
RT peptide expressed in the liver.";
RL Protein Sci. 12:143-152(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 38-77, FUNCTION, AND DISULFIDE BONDS.
RX PubMed=20845358; DOI=10.1002/cbic.201000400;
RA Henriques S.T., Tan C.C., Craik D.J., Clark R.J.;
RT "Structural and functional analysis of human liver-expressed antimicrobial
RT peptide 2.";
RL ChemBioChem 11:2148-2157(2010).
CC -!- FUNCTION: Has an antimicrobial activity. {ECO:0000269|PubMed:20845358}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ306405; CAC51306.1; -; mRNA.
DR EMBL; AJ409064; CAC51515.1; -; Genomic_DNA.
DR EMBL; AJ409065; CAC51516.1; -; mRNA.
DR EMBL; CH471062; EAW62306.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW62307.1; -; Genomic_DNA.
DR EMBL; BC070199; AAH70199.1; -; mRNA.
DR CCDS; CCDS4163.1; -.
DR RefSeq; NP_443203.1; NM_052971.2.
DR PDB; 2L1Q; NMR; -; A=38-77.
DR PDBsum; 2L1Q; -.
DR AlphaFoldDB; Q969E1; -.
DR SMR; Q969E1; -.
DR BioGRID; 125535; 12.
DR STRING; 9606.ENSP00000296877; -.
DR iPTMnet; Q969E1; -.
DR PhosphoSitePlus; Q969E1; -.
DR BioMuta; LEAP2; -.
DR DMDM; 20138667; -.
DR jPOST; Q969E1; -.
DR MassIVE; Q969E1; -.
DR PaxDb; Q969E1; -.
DR PeptideAtlas; Q969E1; -.
DR PRIDE; Q969E1; -.
DR ProteomicsDB; 75739; -.
DR Antibodypedia; 26190; 33 antibodies from 10 providers.
DR DNASU; 116842; -.
DR Ensembl; ENST00000296877.3; ENSP00000296877.2; ENSG00000164406.8.
DR GeneID; 116842; -.
DR KEGG; hsa:116842; -.
DR MANE-Select; ENST00000296877.3; ENSP00000296877.2; NM_052971.3; NP_443203.1.
DR UCSC; uc003kyc.4; human.
DR CTD; 116842; -.
DR DisGeNET; 116842; -.
DR GeneCards; LEAP2; -.
DR HGNC; HGNC:29571; LEAP2.
DR HPA; ENSG00000164406; Tissue enriched (liver).
DR MIM; 611373; gene.
DR neXtProt; NX_Q969E1; -.
DR OpenTargets; ENSG00000164406; -.
DR PharmGKB; PA162393840; -.
DR VEuPathDB; HostDB:ENSG00000164406; -.
DR eggNOG; ENOG502SD5B; Eukaryota.
DR GeneTree; ENSGT00390000013467; -.
DR HOGENOM; CLU_178163_0_0_1; -.
DR InParanoid; Q969E1; -.
DR OMA; SRRMTPF; -.
DR OrthoDB; 1622785at2759; -.
DR PhylomeDB; Q969E1; -.
DR TreeFam; TF336274; -.
DR PathwayCommons; Q969E1; -.
DR Reactome; R-HSA-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 116842; 7 hits in 1043 CRISPR screens.
DR EvolutionaryTrace; Q969E1; -.
DR GenomeRNAi; 116842; -.
DR Pharos; Q969E1; Tbio.
DR PRO; PR:Q969E1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q969E1; protein.
DR Bgee; ENSG00000164406; Expressed in right lobe of liver and 139 other tissues.
DR Genevisible; Q969E1; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IMP:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR InterPro; IPR009955; LEAP-2.
DR PANTHER; PTHR21007; PTHR21007; 1.
DR Pfam; PF07359; LEAP-2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..37
FT /id="PRO_0000017355"
FT CHAIN 38..77
FT /note="Liver-expressed antimicrobial peptide 2"
FT /id="PRO_0000017356"
FT DISULFID 54..65
FT DISULFID 60..70
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:2L1Q"
FT HELIX 57..59
FT /evidence="ECO:0007829|PDB:2L1Q"
SQ SEQUENCE 77 AA; 8814 MW; FD1C300B0F42E4C9 CRC64;
MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI GASCRDDSEC
ITRLCRKRRC SLSVAQE
