LEAP2_MACMU
ID LEAP2_MACMU Reviewed; 77 AA.
AC Q95M25;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Liver-expressed antimicrobial peptide 2;
DE Short=LEAP-2;
DE Flags: Precursor;
GN Name=LEAP2;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12493837; DOI=10.1110/ps.0213603;
RA Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA Wattler F., Wattler S., Adermann K.;
RT "Isolation and biochemical characterization of LEAP-2, a novel blood
RT peptide expressed in the liver.";
RL Protein Sci. 12:143-152(2003).
CC -!- FUNCTION: Has an antimicrobial activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR EMBL; AJ409056; CAC51520.1; -; Genomic_DNA.
DR RefSeq; NP_001107582.1; NM_001114110.1.
DR AlphaFoldDB; Q95M25; -.
DR SMR; Q95M25; -.
DR STRING; 9544.ENSMMUP00000020524; -.
DR Ensembl; ENSMMUT00000041106; ENSMMUP00000034142; ENSMMUG00000015638.
DR GeneID; 709041; -.
DR KEGG; mcc:709041; -.
DR CTD; 116842; -.
DR VEuPathDB; HostDB:ENSMMUG00000015638; -.
DR VGNC; VGNC:74161; LEAP2.
DR eggNOG; ENOG502SD5B; Eukaryota.
DR GeneTree; ENSGT00390000013467; -.
DR HOGENOM; CLU_178163_0_0_1; -.
DR InParanoid; Q95M25; -.
DR OMA; SRRMTPF; -.
DR OrthoDB; 1622785at2759; -.
DR Proteomes; UP000006718; Chromosome 6.
DR Bgee; ENSMMUG00000015638; Expressed in liver and 21 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR009955; LEAP-2.
DR PANTHER; PTHR21007; PTHR21007; 1.
DR Pfam; PF07359; LEAP-2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..37
FT /id="PRO_0000017357"
FT CHAIN 38..77
FT /note="Liver-expressed antimicrobial peptide 2"
FT /id="PRO_0000017358"
FT DISULFID 54..65
FT /evidence="ECO:0000250"
FT DISULFID 60..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8801 MW; FD012D0B125FE4C9 CRC64;
MWHLKLCAVL MIFLLLLGQT DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI GASCRDDSEC
ITRLCRKRRC SLSVAQE