AREA_ASPOR
ID AREA_ASPOR Reviewed; 866 AA.
AC O13415; Q2UU16;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Nitrogen regulatory protein areA;
GN Name=areA; ORFNames=AO090009000502;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=A1560 / IFO 4177;
RX PubMed=9726865; DOI=10.1128/aem.64.9.3232-3237.1998;
RA Christensen T., Hynes M.J., Davis M.A.;
RT "Role of the regulatory gene areA of Aspergillus oryzae in nitrogen
RT metabolism.";
RL Appl. Environ. Microbiol. 64:3232-3237(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Major nitrogen regulatory protein. Positively acting
CC regulatory gene of nitrogen metabolite repression.
CC {ECO:0000269|PubMed:9726865}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; AJ002968; CAA05776.1; -; Genomic_DNA.
DR EMBL; AP007150; BAE54949.1; -; Genomic_DNA.
DR RefSeq; XP_001816951.1; XM_001816899.2.
DR AlphaFoldDB; O13415; -.
DR SMR; O13415; -.
DR STRING; 510516.O13415; -.
DR EnsemblFungi; BAE54949; BAE54949; AO090009000502.
DR GeneID; 5988881; -.
DR KEGG; aor:AO090009000502; -.
DR VEuPathDB; FungiDB:AO090009000502; -.
DR HOGENOM; CLU_009509_0_0_1; -.
DR OMA; WRMMAMS; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR013860; AreA_GATA.
DR InterPro; IPR011420; AreA_N.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 1.
DR Pfam; PF07573; AreA_N; 1.
DR Pfam; PF08550; DUF1752; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 4: Predicted;
KW Activator; DNA-binding; Metal-binding; Nitrate assimilation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..866
FT /note="Nitrogen regulatory protein areA"
FT /id="PRO_0000083464"
FT ZN_FING 664..688
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 92882 MW; C09A03EB12E3FBB4 CRC64;
MSGLTLGRGP GGVRPTQTAT FTTHHPSADA DRSSNNLPPT SSQLSDDFSF GSPLSPADSQ
AHDGLLQDSL FPEWGSGAPR PGIDSPDEMQ RQDPLATQIW KLYSRTKAQL PNQERMENLT
WRMMAMSLKR KERERAQQSM FPARRGSAGP SGIAQLRISD PPVATGNPQS TDLTADPMNL
DDFIVPFESP SDHPSPSAVK ISDSTASAAI PIKSRKDQLR DSTPVPASFH HPAQDQRKNS
EFGYVPRRVR KTSIDERQFF SLQVPTRKRP AESSPQVPPV SNSMLAHDPD LASGVPDYAL
DAPSSAFGFH QGNHHPVNHH NHTSPGAPFG LDTFGLGDDP ILPSAGPYQS QFTFSPSESP
MASGHPFANL YSHTPVASSL NSTDFFSPPP SGYQSTASTP QPTYDGDHSV YFDMPSGDAR
TQRRIPNYIS HRSNLSASLQ PRYMFNQNNH EQASSSTVHS PSYPIPQPQH VDPTQVLNAT
NYSTGNSHHT GAMFSFGADS DNEDDDGHQL SERAGLAMPT EYGDEDGFSS GMQWDGQFPG
SFHSLPGFGP QHRKHVTIGS TDMMDTPEEW NHGGSLGRTH GSVASVSEVR NREQDPRRQK
IARTTSTPNT AQLLRQSMHS NNNTSHTSPN TPPESALSSA VPSRPASPGG SKNGDQGSNG
PTTCTNCFTQ TTPLWRRNPE GQPLCNACGL FLKLHGVVRP LSLKTDVIKK RNRSSANSLA
VGTSRASKKT ARKNSVQQAS VTTPTSSRAQ NGTSFESPPA GFSAAAGRSN GVVPIAAAPP
KAAPSAAASP STGQTRNPIQ AAPKRQRRLE KATEMETDEA NKSAGGRSKV VPLAPAMPPA
AANPANHSIA GGQGASQEWE WLTMSL
