LEAP2_MOUSE
ID LEAP2_MOUSE Reviewed; 76 AA.
AC Q91V13; Q5EBH6;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Liver-expressed antimicrobial peptide 2;
DE Short=LEAP-2;
DE Flags: Precursor;
GN Name=Leap2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv; TISSUE=Small intestine;
RX PubMed=12493837; DOI=10.1110/ps.0213603;
RA Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA Wattler F., Wattler S., Adermann K.;
RT "Isolation and biochemical characterization of LEAP-2, a novel blood
RT peptide expressed in the liver.";
RL Protein Sci. 12:143-152(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has an antimicrobial activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR EMBL; AJ409055; CAC51472.1; -; mRNA.
DR EMBL; AJ409063; CAC51519.1; -; Genomic_DNA.
DR EMBL; BC089593; AAH89593.1; -; mRNA.
DR CCDS; CCDS36150.1; -.
DR RefSeq; NP_694709.1; NM_153069.3.
DR AlphaFoldDB; Q91V13; -.
DR SMR; Q91V13; -.
DR STRING; 10090.ENSMUSP00000044166; -.
DR PhosphoSitePlus; Q91V13; -.
DR PaxDb; Q91V13; -.
DR PRIDE; Q91V13; -.
DR Antibodypedia; 26190; 33 antibodies from 10 providers.
DR DNASU; 259301; -.
DR Ensembl; ENSMUST00000036045; ENSMUSP00000044166; ENSMUSG00000036216.
DR GeneID; 259301; -.
DR KEGG; mmu:259301; -.
DR UCSC; uc007ivx.1; mouse.
DR CTD; 116842; -.
DR MGI; MGI:2672795; Leap2.
DR VEuPathDB; HostDB:ENSMUSG00000036216; -.
DR eggNOG; ENOG502SD5B; Eukaryota.
DR GeneTree; ENSGT00390000013467; -.
DR HOGENOM; CLU_178163_0_0_1; -.
DR InParanoid; Q91V13; -.
DR OMA; SRRMTPF; -.
DR OrthoDB; 1622785at2759; -.
DR PhylomeDB; Q91V13; -.
DR TreeFam; TF336274; -.
DR Reactome; R-MMU-6803157; Antimicrobial peptides.
DR BioGRID-ORCS; 259301; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Leap2; mouse.
DR PRO; PR:Q91V13; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q91V13; protein.
DR Bgee; ENSMUSG00000036216; Expressed in small intestine Peyer's patch and 39 other tissues.
DR Genevisible; Q91V13; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; ISO:MGI.
DR InterPro; IPR009955; LEAP-2.
DR PANTHER; PTHR21007; PTHR21007; 1.
DR Pfam; PF07359; LEAP-2; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..36
FT /evidence="ECO:0000255"
FT /id="PRO_0000017359"
FT CHAIN 37..76
FT /note="Liver-expressed antimicrobial peptide 2"
FT /id="PRO_0000017360"
FT DISULFID 53..64
FT /evidence="ECO:0000250"
FT DISULFID 59..69
FT /evidence="ECO:0000250"
SQ SEQUENCE 76 AA; 8536 MW; E0E1BE1595FE1ACC CRC64;
MLQLKLFAVL LTCLLLLGQV NSSPVPEVSS AKRSRRMTPF WRGVSLRPIG ASCRDDSECI
TRLCRKRRCS LSVAQE
