ID   LEAP2_PIG               Reviewed;          77 AA.
AC   Q95JB4;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Liver-expressed antimicrobial peptide 2;
DE            Short=LEAP-2;
DE   Flags: Precursor;
GN   Name=LEAP2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=12493837; DOI=10.1110/ps.0213603;
RA   Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA   Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA   Wattler F., Wattler S., Adermann K.;
RT   "Isolation and biochemical characterization of LEAP-2, a novel blood
RT   peptide expressed in the liver.";
RL   Protein Sci. 12:143-152(2003).
CC   -!- FUNCTION: Has an antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR   EMBL; AJ409013; CAC51475.1; -; mRNA.
DR   AlphaFoldDB; Q95JB4; -.
DR   SMR; Q95JB4; -.
DR   STRING; 9823.ENSSSCP00000015201; -.
DR   PaxDb; Q95JB4; -.
DR   eggNOG; ENOG502SD5B; Eukaryota.
DR   InParanoid; Q95JB4; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR009955; LEAP-2.
DR   PANTHER; PTHR21007; PTHR21007; 1.
DR   Pfam; PF07359; LEAP-2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..37
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000017361"
FT   CHAIN           38..77
FT                   /note="Liver-expressed antimicrobial peptide 2"
FT                   /id="PRO_0000017362"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8818 MW;  BB2E8280FB54B6F2 CRC64;
     MWHLKLFAVL VICLLLAVQV HGSPIPELSS AKRRPRRMTP FWRAVSLRPI GASCRDDSEC
     LTRLCRKRRC SLSVAQE