ID   LEB4_BOMMO              Reviewed;         179 AA.
AC   O15946;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Lebocin-4;
DE            Short=Leb 4;
DE   Flags: Precursor;
GN   Name=LEB4;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tokai X Asahi;
RX   PubMed=9325165; DOI=10.1006/bbrc.1997.7386;
RA   Furukawa S., Taniai K., Ishibashi J., Hara S., Shono T., Yamakawa M.;
RT   "A novel member of lebocin gene family from the silkworm, Bombyx mori.";
RL   Biochem. Biophys. Res. Commun. 238:769-774(1997).
CC   -!- FUNCTION: Antibacterial peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Hemolymph. Produced in fat body.
CC   -!- INDUCTION: By bacterial infection.
CC   -!- PTM: O-glycosylation is important for the antibacterial activity of
CC       lebocin.
CC   -!- SIMILARITY: Belongs to the lebocin family. {ECO:0000305}.
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DR   EMBL; AB003036; BAA22884.1; -; Genomic_DNA.
DR   PIR; JC5666; JC5666.
DR   RefSeq; NP_001119731.1; NM_001126259.1.
DR   AlphaFoldDB; O15946; -.
DR   HOGENOM; CLU_128921_0_0_1; -.
DR   InParanoid; O15946; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Glycoprotein; Immunity; Innate immunity;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..120
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004980"
FT   PEPTIDE         121..152
FT                   /note="Lebocin-4"
FT                   /id="PRO_0000004981"
FT   PROPEP          153..179
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004982"
FT   CARBOHYD        135
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   179 AA;  21064 MW;  043C150754471107 CRC64;
     MYKFLVFSSV LVLFFAQASC QRFIQPTYRP PPTRRPIIRT ARQAGQEPLW LYQGDNIPRA
     PSTADHPILP SKIDDVKLDP NRRYVRSVTN PENNEASIES SHHTVDIGLD RPIESHRNTR
     DLRFWNPREK LPLPTLPPFN PKPIYIDMGN RYRRHASDDQ EELRHHNEHF LIPRDILQD