LEC1_CAEEL
ID LEC1_CAEEL Reviewed; 279 AA.
AC P36573;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=32 kDa beta-galactoside-binding lectin;
DE AltName: Full=32 kDa GBP;
GN Name=lec-1; ORFNames=W09H1.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1639789; DOI=10.1016/s0021-9258(19)49560-4;
RA Hirabayashi J., Satoh M., Kasai K.;
RT "Evidence that Caenorhabditis elegans 32-kDa beta-galactoside-binding
RT protein is homologous to vertebrate beta-galactoside-binding lectins. cDNA
RT cloning and deduced amino acid sequence.";
RL J. Biol. Chem. 267:15485-15490(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9334250; DOI=10.1074/jbc.272.42.26669;
RA Arata Y., Hirabayashi J., Kasai K.;
RT "Structure of the 32-kDa galectin gene of the nematode Caenorhabditis
RT elegans.";
RL J. Biol. Chem. 272:26669-26677(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP PROTEIN SEQUENCE OF 202-220.
RX PubMed=1639749; DOI=10.1093/oxfordjournals.jbchem.a123794;
RA Hirabayashi J., Satoh M., Ohyama Y., Kasai K.;
RT "Purification and characterization of beta-galactoside-binding proteins
RT from Caenorhabditis elegans.";
RL J. Biochem. 111:553-555(1992).
CC -!- FUNCTION: Binds galactose.
CC -!- PTM: The N-terminus is blocked.
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DR EMBL; M94671; AAB87718.1; -; mRNA.
DR EMBL; AB000802; BAA22942.1; -; Genomic_DNA.
DR EMBL; Z82081; CAB04959.1; -; Genomic_DNA.
DR PIR; PX0062; PX0062.
DR PIR; T37216; T37216.
DR RefSeq; NP_496801.2; NM_064400.5.
DR AlphaFoldDB; P36573; -.
DR SMR; P36573; -.
DR BioGRID; 40260; 86.
DR DIP; DIP-26872N; -.
DR IntAct; P36573; 1.
DR STRING; 6239.W09H1.6b; -.
DR World-2DPAGE; 0011:P36573; -.
DR World-2DPAGE; 0020:P36573; -.
DR EPD; P36573; -.
DR PaxDb; P36573; -.
DR PeptideAtlas; P36573; -.
DR EnsemblMetazoa; W09H1.6a.1; W09H1.6a.1; WBGene00002264.
DR GeneID; 174964; -.
DR UCSC; W09H1.6a; c. elegans.
DR CTD; 174964; -.
DR WormBase; W09H1.6a; CE16576; WBGene00002264; lec-1.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000173978; -.
DR HOGENOM; CLU_037794_1_1_1; -.
DR InParanoid; P36573; -.
DR Reactome; R-CEL-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-8957275; Post-translational protein phosphorylation.
DR PRO; PR:P36573; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00002264; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; P36573; baseline and differential.
DR GO; GO:0060102; C:collagen and cuticulin-based cuticle extracellular matrix; IDA:WormBase.
DR GO; GO:0045121; C:membrane raft; HDA:WormBase.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016936; F:galactoside binding; IDA:WormBase.
DR CDD; cd00070; GLECT; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR Pfam; PF00337; Gal-bind_lectin; 2.
DR SMART; SM00908; Gal-bind_lectin; 2.
DR SMART; SM00276; GLECT; 2.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS51304; GALECTIN; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Lectin; Reference proteome; Repeat.
FT CHAIN 1..279
FT /note="32 kDa beta-galactoside-binding lectin"
FT /id="PRO_0000076957"
FT DOMAIN 13..144
FT /note="Galectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT DOMAIN 152..279
FT /note="Galectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT BINDING 213..219
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000250"
SQ SEQUENCE 279 AA; 31810 MW; ED9AE22AE37571DA CRC64;
MSAEEPKSYP VPYRSVLQEK FEPGQTLIVK GSTIDESQRF TINLHSKTAD FSGNDVPLHV
SVRFDEGKIV LNSFSNGEWG KEERKSNPIK KGDSFDIRIR AHDDRFQIIV DHKEFKDYEH
RLPLSSISHL SIDGDLYLNH VHWGGKYYPV PYESGLANGL PVGKSLLVFG TVEKKAKRFH
VNLLRKNGDI SFHFNPRFDE KHVIRNSLAA NEWGNEEREG KNPFEKGVGF DLVIQNEEYA
FQVFVNGERY ISFAHRADPH DIAGLQISGD IELSGIQIQ
