LEC1_HYPMC
ID LEC1_HYPMC Reviewed; 90 AA.
AC P84871;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Lectin-1;
DE AltName: Full=HCA;
DE Contains:
DE RecName: Full=Lectin-1 N-terminal subunit;
DE Contains:
DE RecName: Full=Lectin-1 C-terminal subunit;
OS Hypnea musciformis (Red alga) (Fucus musciformis).
OC Eukaryota; Rhodophyta; Florideophyceae; Rhodymeniophycidae; Gigartinales;
OC Hypneaceae; Hypnea.
OX NCBI_TaxID=31429;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, FUNCTION, CLEAVAGE,
RP DISULFIDE BONDS, AND MASS SPECTROMETRY.
RX PubMed=16046632; DOI=10.1110/ps.051498505;
RA Nagano C.S., Debray H., Nascimento K.S., Pinto V.P.T., Cavada B.S.,
RA Saker-Sampaio S., Farias W.R.L., Sampaio A.H., Calvete J.J.;
RT "HCA and HML isolated from the red marine algae Hypnea cervicornis and
RT Hypnea musciformis define a novel lectin family.";
RL Protein Sci. 14:2167-2176(2005).
CC -!- FUNCTION: Lectin with specificity for complex N-linked glycans and O-
CC linked glycans. Has hemagglutinating activity towards rabbit
CC erythrocytes. {ECO:0000269|PubMed:16046632}.
CC -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:16046632}.
CC -!- PTM: Contains seven disulfide bonds. {ECO:0000269|PubMed:16046632,
CC ECO:0000305}.
CC -!- PTM: Proteolytically cleaved. Major mature form may consist of cleaved,
CC disulfide-bonded N-terminal and C-terminal chains.
CC {ECO:0000269|PubMed:16046632}.
CC -!- MASS SPECTROMETRY: [Lectin-1]: Mass=9357; Mass_error=1; Method=MALDI;
CC Note=The measured mass is that of the native single chain.;
CC Evidence={ECO:0000269|PubMed:16046632};
CC -!- MASS SPECTROMETRY: [Lectin-1]: Mass=10161; Method=MALDI; Note=The
CC measured mass is that of the reduced and carbamidomethylated single
CC chain.; Evidence={ECO:0000269|PubMed:16046632};
CC -!- MASS SPECTROMETRY: [Lectin-1 N-terminal subunit]: Mass=5734;
CC Method=MALDI; Note=The measured mass is that of the reduced and
CC carbamidomethylated N-terminal chain.;
CC Evidence={ECO:0000269|PubMed:16046632};
CC -!- MASS SPECTROMETRY: [Lectin-1 C-terminal subunit]: Mass=4460;
CC Method=MALDI; Note=The measured mass is that of the reduced and
CC carbamidomethylated C-terminal chain.;
CC Evidence={ECO:0000269|PubMed:16046632};
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DR AlphaFoldDB; P84871; -.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hemagglutinin; Lectin;
KW Pyrrolidone carboxylic acid.
FT CHAIN 1..90
FT /note="Lectin-1"
FT /id="PRO_0000245161"
FT CHAIN 1..50
FT /note="Lectin-1 N-terminal subunit"
FT /id="PRO_0000245162"
FT CHAIN 51..90
FT /note="Lectin-1 C-terminal subunit"
FT /id="PRO_0000245163"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:16046632"
FT DISULFID 46..71
FT /note="Interchain (between N-terminal and C-terminal
FT subunits)"
FT /evidence="ECO:0000305|PubMed:16046632"
SQ SEQUENCE 90 AA; 9365 MW; FB71D2F9E7349A48 CRC64;
QKFCTLDIAP VCCQIVIGGG MYTAGNACMC EGFVSGVGRC ENPKECPCTR EAQIPSCCSS
RWGLVSVTGK CACDCLGGTV AFPEPCPSPY